塑料型喷雾剂泵目标元素测定方法的研究  

Determination Method of Elements in Plastic Spray Pump

作　　者：陈雪帆 施咨含 CHEN Xue-fan;SHI Zi-han(Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals,Zhejiang University of Technology,Hangzhou 310014,China;Key Laboratory of Pharmaceutical Engineering of Zhejiang Province,Key Laboratory of Ministry of Education,Hangzhou 310014,China)

机构地区：[1]浙江工业大学绿色制药协同创新中心,杭州310014 [2]教育部重点实验室浙江省制药工程重点实验室,杭州310014

出　　处：《包装工程》2023年第21期267-272,共6页Packaging Engineering

基　　金：浙江省药品接触材料质量控制研究重点实验室开放基金资助项目(2014E10006)。

摘　　要：目的建立塑料型喷雾剂泵中12种元素的电感耦合等离子质谱(ICP-MS)测定方法,并用于测定盐酸羟甲唑啉喷雾剂中的元素含量。方法采用微波消解法进行样品前处理,使用ICP-MS法测定塑料型喷雾剂泵中硼、铝、钛、铬、锰、铁、锌、镍、砷、钼、镉、铅等12种元素含量。结果每个元素在0~500 ng/mL浓度范围内线性良好,相关系数r均大于0.99,检测限为0.02~1.71μg/kg,各元素的加标回收率为92.62%~113.82%,相对标准偏差(RSD)为0.64%~3.41%。采用本方法测定盐酸羟甲唑啉喷雾剂,研究在加速条件下喷雾剂中元素的含量迁移变化,结果为各元素含量均未超过浓度限度。结论本方法前处理简便、方法准确、灵敏度较高,能够高效快速地测定塑料型喷雾剂泵中元素的含量。The work aims to establish an ICP-MS method to detect 12 elements in plastic spray pump,and determine the contents of elements in hydroxymethazoline hydrochloride spray.The method of microwave digestion was used for sample pretreatment,and 12 elements including boron,aluminum,titanium,chromium,manganese,iron,zinc,nickel,arsenic,molybdenum,cadmium and lead in plastic spray pump were tested by ICP-MS.For each element,there was a favorable linearity in the range of 0-500 ng/mL with the correlation coefficients r>0.99.The detection limit of this method was 0.02-1.71μg/kg,the rate of recovery was 92.62%-113.82% and the relative standard deviation(RSD)was 0.64%-3.41%.At the same time,with hydroxymethazoline hydrochloride spray as an example,the content migration of elements in the spray was studied under the condition of acceleration,and the results showed that all elements did not exceed the concentration limit.This method established in this work is convenient for sample pretreatment,accurate and highly sensitive and can determine the contents of 12 elements in plastic spray pump rapidly and efficiently.

关 键 词：喷雾剂泵 电感耦合等离子质谱 微波消解法 元素测定 

分 类 号：TB484[一般工业技术—包装工程] O657.63[理学—分析化学]