卡痛叶中生物碱类活性成分研究进展  

Research Advances of Alkaloid Active Ingredients in Kratom

作　　者：李玉静[1] 何洪源[1] 李润康 赵霞 LI Yu-jing;HE Hong-yuan;LI Run-kang;ZHAO Xia(School of Criminal Investigation,People’s Public Security University of China,Beijing 100038,China;CAAC Central and Southern Regional Administration,Guangzhou 510545,China;National Anti-Drug Laboratory Beijing Regional Center,Beijing 100164,China)

机构地区：[1]中国人民公安大学侦查学院,北京100038 [2]中国民用航空中南地区管理局公安局,广东广州510545 [3]国家毒品实验室北京分中心,北京100164

出　　处：《分析测试学报》2023年第11期1524-1532,共9页Journal of Instrumental Analysis

基　　金：中国人民公安大学刑事科学技术双一流创新研究专项(2023SYL06)。

摘　　要：卡痛叶是植物卡痛树的叶子,含有丰富的生物碱,其主要生物碱类活性成分帽柱木碱(Mitragynine)和7-羟基帽柱木碱(7-Hydroxymitragynine)是多阿片受体激动剂,过量摄入能使人产生药物依赖甚至中毒死亡。近年来,卡痛叶在全球范围内的滥用现象日益严重,已成为应用最广泛的植物类新精神活性物质,许多国家将其列为非法物质,并对其活性成分进行了广泛研究。该文介绍了卡痛叶生物碱类活性成分、其药理毒理作用和体内代谢过程,综述了气相色谱-质谱联用法、高效液相色谱法、液相色谱-质谱联用法等常规检验方法和质谱法、免疫分析法等快检方法在卡痛叶生物碱类活性成分检验研究中的最新进展,以期为卡痛叶中生物碱类活性成分的准确鉴定提供参考。The leaves of the plant kratom tree are rich in alkaloids,of which the main alkaloid active ingredients,mitragynine and 7-hydroxymitragynine are polyopioid receptor agonists,and the excessive intake of kratom can cause drug dependence and even death.In recent years,kratom is increasingly abused worldwide,and has become the most widely used plant-based new psychoactive substance.Many countries have classified kratom as an illegal substance and conducted extensive research on its active ingredients.In this paper,the active ingredients of kratom,their pharmacological and toxicological properties and metabolic processes in vivo are introduced,and the latest progress of conventional testing methods such as gas chromatography-mass spectrometry,high performance liquid chromatography,liquid chromatography-mass spectrometry,as well as rapid detection methods such as mass spectrometry and immunoanalysis,for the detection of alkaloids active ingredients in kratom are reviewed,in order to provide reference for the accurate identification of the alkaloid active ingredients of kratom.

关 键 词：卡痛叶 活性成分 生物碱 体内代谢 检验方法 毒理学 

分 类 号：O657.7[理学—分析化学] O629.3[理学—化学]