寄生虫免疫逃避的研究进展  

ADVANCES ON IMMUNE EVASION OF PARASITES

作　　者：韩利方[1] 索勋[2] 闫文朝[1] HAN Li-fang;SUO Xun;YAN Wen-chao(College of Animal Science and Technology,Henan University of Science and Technology,Luoyang 471023,Henan,China;College of Veterinary Medicine,China Agricultural University,Beijing 100193,China)

机构地区：[1]河南科技大学动物科技学院,河南洛阳471023 [2]中国农业大学动物医学院,北京100193

出　　处：《寄生虫与医学昆虫学报》2023年第3期180-186,共7页Acta Parasitologica et Medica Entomologica Sinica

基　　金：国家自然科学基金项目(No.31772733);河南省自然科学基金项目(182300410088)。

摘　　要：寄生虫是人和动物重要的病原,严重危害人类和动物的健康。寄生虫与宿主在长期的共进化过程中,形成了复杂而巧妙的免疫逃避能力,能有效地规避宿主免疫系统的识别和杀伤。本文结合国内外研究结果,从逃避免疫识别、免疫抑制和借力共感染3个方面来论述和分析寄生虫感染的免疫逃避机制,以期提高读者对寄生虫感染复杂性和危害性的认识,为人和动物寄生虫病的有效防控提供重要参考和指导。Parasite is an important pathogen and seriously threats the health of humans and animals.With long coevolution with its host,parasite has formed the complicated and smart ability to evade immune recognition and kill of its host.In combined with novel progress of parasitic immunity,the mechanisms of immune evasion are summarized and discussed based on three aspects including evading immune recognition,immunosuppression and leveraging co-infections in parasitic infections.It is expected to improve the understanding of the complexity and risk of parasitic infections,and provide an important reference and guide for control of parasitosis in humans and animals.

关 键 词：寄生虫 免疫逃避 免疫抑制 共感染 

分 类 号：R53[医药卫生—内科学]