2%夫西地酸乳膏联合透明质酸治疗丘疹脓疱型玫瑰痤疮的临床观察  

Clinical observation on the treatment of papular pustular rosacea with 2%Fusidic acid cream combined with hyaluronic acid

作　　者：谢成树 周顶峰 李敏[1] 任盛超 李军志 XIE Chengshu;ZHOU Dingfeng;LI Min;REN Shengchao;LI Junzhi(Tongling Center for Disease Control and Prevention,Tongling 244000,China)

机构地区：[1]铜陵市疾病预防控制中心,安徽铜陵244000

出　　处：《皮肤性病诊疗学杂志》2023年第5期428-432,共5页Journal of Diagnosis and Therapy on Dermato-venereology

摘　　要：目的评价2%夫西地酸乳膏联合透明质酸治疗丘疹脓疱型玫瑰痤疮的临床疗效。方法将72例丘疹脓疱型玫瑰痤疮患者随机分为透明质酸组和对照组,每组各36例。两组均给予口服多西环素100 mg,每天1次,共6周;外用2%夫西地酸乳膏,每天2次,共4周。透明质酸组同时外用透明质酸,每天2次,共8周。在初诊和复诊2、4、8周时,记录两组患者的研究者总体评价得分(IGA)、炎性丘疹数、皮肤病学生活质量指数(DLQI)评分、症状评分,并进行比较。结果最终69例完成疗效评价。第2周时,透明质酸组临床治愈者占比(χ^(2)=4.70,P=0.013)、DLQI评分发生最小临床重要差异(MCID)的百分比(χ^(2)=4.14,P=0.020)均高于对照组,而第4、8周时无明显差异(均P>0.05)。两组炎性丘疹数在观察期间均无明显差异(均P>0.05)。透明质酸组症状评分在第2周(t=-2.63,P=0.011)、第4周(t=-4.62,P<0.001)时低于对照组,而第8周时无明显差异。结论2%夫西地酸乳膏治疗玫瑰痤疮的同时联合应用透明质酸,可以快速改善临床症状,提高患者早期生活质量。Objective To evaluate the clinical efficacy of 2%Fusidic acid cream combined with hyaluronic acid in the treatment of papular pustular rosacea.Methods Seventy-two patients were randomly divided into the hyaluronic acid and the control groups,36 patients per group.Both groups were given oral doxycycline 100 mg,qd for 6 weeks and topical 2%Fusidic acid cream twice daily for 4 weeks.In the hyaluronic acid group,topical hyaluronic acid was also given twice daily for 8 weeks.At the enrollment,2-,4-,and 8-week follow-up,the IGA,number of inflammatory papules,DLQI score,and symptom score were compared between the two groups.Results Out of the 72 patients,69 patients completed the study.Following 2 weeks of the treatment,both the cure rate and the rate of minimal clinically important difference(MCID)were significant higher in the hyaluronic acid group than in the controls(χ^(2)=4.70,P=0.013 for cure rate;2=4.14,P=0.020 for MCID).However,neither the cure rate nor the rate of MCID differed significantly between the two groups at 4-and 8-week follow-up.Moreover,the symptom scores were lower in the hyaluronic acid group than in the controls at 2-and 4-week(t=-2.63,P=0.011;t=-4.62,P<0.001),but not at 8-week follow-up.Conclusion Treatments of rosacea with the combination of 2%Fusidic acid cream and hyaluronic acid can rapidly improve clinical symptoms and the quality of patients′lives.

关 键 词：透明质酸 玫瑰痤疮 研究者总体评价得分 皮肤病学生活质量指数 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]