干燥综合征相关的小纤维神经病研究进展  

Research progress in small fiber neuropathy associated with Sjogren′s syndrome

作　　者：徐礼英 张佳玉 王尔鹏 刘雨鑫 袁超[1] XU Liying;ZHANG Jiayu;WANG Erpeng;LIU Yuxin;YUAN Chao(Nanfang Hospital,Southern Medical University;Southern Medical University,Guangzhou 510510,China)

机构地区：[1]南方医科大学南方医院 [2]南方医科大学,广东广州510510

出　　处：《皮肤性病诊疗学杂志》2023年第5期455-459,共5页Journal of Diagnosis and Therapy on Dermato-venereology

基　　金：国家自然科学基金(8200052163)。

摘　　要：在干燥综合征(SS)合并的神经病变中,周围神经病中的小纤维神经病变最常见。小纤维神经病(SFN)是指特异性累及有髓Aδ纤维与无髓c纤维的神经病,神经生理检查异常和/或皮肤活检中表皮内神经纤维密度减少。SS合并SFN患者临床上多表现为疼痛、灼热感,可伴有自主神经功能障碍。此类患者神经系统临床表现可能早于SS的诊断,故早期识别和治疗有助于减轻痛苦。本文对SS相关的SFN研究进展进行综述,包括疾病的病理基础和可能的分子生物学机制、临床症状、诊断和治疗方法,为SS相关的SFN临床诊疗提供参考。Small fiber neuropathy(SFN)in peripheral neuropathies is the most common neuropathy associated with Sjogren′s syndrome(SS).Small fiber neuropathy is a neuropathy that specifically involves myelinated Aδand unmyelinated c-fibers,with abnormal neurophysiology and/or reduced intraepidermal nerve fiber density in the skin biopsy.Patients with Sjogren′s syndrome complicated with small fiber neuropathy often present with painful and burning sensation,accompanied by autonomic dysfunction.In these patients,neurologic clinical manifestations may precede the diagnosis of Sjogren′s syndrome.Thus,early diagnosis and treatment may help to reduce the suffering of the patients.This article reviews the research progress in small fiber neuropathy associated with Sjogren′s syndrome,including the pathological basis,possible molecular mechanisms,clinical symptoms,the diagnosis and treatment in order to benefit the research,diagnosis and management of this disease.

关 键 词：干燥综合征 小纤维神经病 周围神经病 治疗 

分 类 号：R593.2[医药卫生—内科学]