慢性瘙痒性皮肤病的神经-免疫机制研究进展  

Advances in neuro-immune interactions in chronic pruritic dermatoses

作　　者：李欣然[1] 陈尧[1] 李凤仙[1] LI Xinran;CHEN Yao;LI Fengxian(Zhujiang Hospital,Southern Medical University,Guangzhou 510280,China)

机构地区：[1]南方医科大学珠江医院,广东广州510280

出　　处：《皮肤性病诊疗学杂志》2023年第5期465-470,共6页Journal of Diagnosis and Therapy on Dermato-venereology

基　　金：国家自然科学基金(81974192)。

摘　　要：慢性瘙痒是多种皮肤疾病以及全身性疾病的临床表现,长期慢性瘙痒可导致生活质量严重下降。目前传统治疗方式疗效欠佳,慢性瘙痒的治疗面临诸多困难。因此,探讨慢性瘙痒的发病机制,对新型药物研发与治疗策略的选择至关重要。本文聚焦皮肤“神经-免疫”之间的相互作用,综述其在特异性皮炎、银屑病、糖尿病皮肤瘙痒、不明原因皮肤瘙痒等瘙痒性疾病中的作用机制研究进展,阐明神经-免疫在皮肤炎症调节以及慢性瘙痒病理过程中的重要作用,为临床治疗及药物研发提供参考。Chronic pruritus is a clinical manifestation of a variety of cutaneous and systemic diseases.Persist chronic pruritus leads to a decreased quality of life.Nowadays the efficacy of traditional therapeutic regimens is not satisfactory,and the treatment of chronic pruritus is facing difficulties.Therefore,it is crucial to explore the pathogenesis of chronic pruritus and to develop new therapeutic strategies,including targeted drugs.This review focuses on the interaction between sensory terminals and immune cells in the skin and summarizes the progress on the mechanisms of chronic pruritic diseases such as atopic dermatitis,psoriasis,diabetic pruritus,and chronic pruritus of unknown origin.To elucidate the regulatory role of neuroimmune interaction in cutaneous inflammation and the pathological process of chronic pruritus can facilitate future basic and clinical research.

关 键 词：慢性瘙痒 瘙痒机制 神经免疫 

分 类 号：R751[医药卫生—皮肤病学与性病学]