2017—2021年广州市某手足口病哨点监测医院病原学监测结果分析  

Etiologic analysis of hand,foot,and mouth disease in a sentinel surveillance hospital in Guangzhou City in 2017-2021

作　　者：黄建英[1] 刘妙玲[1] 蔡建 李静静[1] 王珂 邹晓妮[1] HUANG Jianying;LIU Miaoling;CAI Jian;LI Jingjing;WANG Ke;ZOU Xiaoni(Department of Nosocomial Infection Management,Guangdong Women and Children Hosptial,Guangzhou,Guangdong 511442,China)

机构地区：[1]广东省妇幼保健院,广东广州511442

出　　处：《公共卫生与预防医学》2023年第6期61-64,共4页Journal of Public Health and Preventive Medicine

基　　金：广东省医学科研基金项目(C2022039)。

摘　　要：目的分析2017—2021年广州市某手足口病哨点监测医院手足口病病原学监测结果,了解手足口病病原学特征,为手足口病的防控提供科学依据。方法采用描述性流行病学方法,对2017—2021年手足口病轻症监测病例病原学结果进行分析。结果2017—2021年共监测1663例手足口病轻症病例,肠道病毒通用检测阳性率78.41%,其中主要致病原Cox A6、Cox A16、Cox A10、EV 71的阳性率分别为40.83%、17.68%、6.13%和1.62%。各年份肠道病毒总阳性率、各型别肠道病毒阳性率差异均有统计学意义(P<0.001),2017—2021年广州地区手足口病主要以Cox A6流行为主,其次是Cox A16,2018年阳性率最高为24.62%;EV 71的检出阳性率逐年降低。Cox A6在每年6~12月高位流行,每年4~8月份Cox A16检出率较高;2017年1~5月份EV 71阳性检出率较高,2018—2021年检出率低,无流行高峰期。结论广州市2017—2021年手足口病流行的主要病原体是Cox A6,EV 71和Cox A16不再是主要病原体,提示加强手足口病病原学流行趋势监测,对手足口病的防控有重要意义。Objective To investigate etiologic characteristics of hand,foot,and mouth disease(HFMD)in a sentinel hospital in Guangzhou from 2017 to 2021,and to provide a scientific basis for the prevention and control of HFMD.Methods Descriptive epidemiologic methods were used to analyze the etiologic characteristics of mild cases of HMFD during 2017-2021.Results A total of 1633 specimens of mild cases of HMFD were collected from 2017 to 2021.The total enterovirus(EV)positive rate was 78.41%,among which the positive rates of the main pathogen Cox A6,Cox A16,Cox A10,and EV71 were 40.83%,17.68%,6.13%,and 1.62%,respectively.The total positive rate of enteroviruses and the positive rate of enteroviruses of all types in each year were statistically different(P<0.001).In 2017-2021,the prevalence of HFMD in Guangzhou was mainly Cox A6,followed by Cox A16 which had the highest positive rate in 2018(24.62%).The positive rate of EV71 decreased year by year.Cox A6 was highly prevalent from June to December every year,while the detection rate of Cox A16 was high from April to August every year.The positive detection rate of EV71 was high from January to May in 2017 and low from 2018 to 2021,with no epidemic peak.Conclusion From 2017 to 2021,the main pathogen of HMFD in Guangzhou is Cox A6,not EV71 or CoxA16,which suggests that it is of great significance to strengthen the monitoring of epidemic trend of HFMD for the prevention and control of HFMD.

关 键 词：手足口病 病原学 流行病学 

分 类 号：R183[医药卫生—流行病学]