GDF-9和BMP-15在PCOS卵泡发育及胰岛素抵抗中的研究进展  

Research Progress of GDF-9 and BMP-15 on Follicular Development and Insulin Resistance in PCOS

作　　者：张宇杰 王文成 张宁(审校)[2] ZHANG Yu-jie;WANG Wen-cheng;ZHANG Ning(The First Clinical Medical College of Shandong University of Traditional Chinese Medicine,Jinan 250000,China;Center of Reproduction and Genetics,Shandong Provincial Hospital of Traditional Chinese Medicine,Jinan 250000,China)

机构地区：[1]山东中医药大学第一临床医学院,济南250000 [2]山东省中医院生殖与遗传中心

出　　处：《国际生殖健康／计划生育杂志》2023年第6期487-491,共5页Journal of International Reproductive Health/Family Planning

基　　金：山东省自然科学基金面上项目(ZR2021MH003)。

摘　　要：生长分化因子-9(growth differentiation factor-9,GDF-9)和骨形态生成蛋白-15(bone morphogenetic protein-15,BMP-15)是转化生长因子-β(transforming growth factor-β,TGF-β)超家族的组成部分,在卵巢中参与颗粒细胞和卵母细胞的增殖分化,影响卵母细胞的发育和质量,调节卵巢功能。GDF-9和BMP-15异常表达,影响卵泡发育和透明带结构,可能是导致多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者不孕的重要环节。BMP-15激活Smad1/5/8信号通路,可能还与PCOS患者的胰岛素抵抗密切相关。但是,血清中GDF-9和BMP-15蛋白难以精确定量,血清GDF-9和BMP-15水平难以作为PCOS特异性诊断与治疗评估的标志。综述GDF-9和BMP-15在卵泡发育中的作用、PCOS患者卵巢GDF-9和BMP-15异常表达对卵泡发育及胰岛素抵抗的影响,探讨GDF-9和BMP-15在PCOS诊治中的潜在应用价值。Growth differentiation factor-9(GDF-9)and bone morphogenetic protein-15(BMP-15)are two members of the transforming growth factor-β(TGF-β)superfamily,which participate in the proliferation and differentiation of granulosa cells and oocytes in the ovary.The GDF-9 and BMP-15 secreted by oocyte affect the development and quality of oocytes,and regulate ovarian function,by the interaction between oocyte and cumulus cells.The abnormal expressions of GDF-9 and BMP-15 affect follicular development and zona pellucida structure,which may be an important link leading to infertility in women with polycystic ovary syndrome(PCOS).BMP-15 activates the Smad1/5/8 signaling pathway,which is closely related to insulin resistance(IR)in PCOS patients.However,the precise quantification of serum GDF-9 and BMP-15 levels is difficult,and the levels of serum GDF-9 and BMP-15 are difficult to be used as specific markers for the diagnosis and treatment evaluation of PCOS.This article reviews the roles of GDF-9 and BMP-15 in follicular development,the effects of abnormal expression of GDF-9 and BMP-15 on follicular development and IR in PCOS patients,and discusses the potential application value of GDF-9 and BMP-15 in the diagnosis and treatment of PCOS.

关 键 词：生长分化因子9 骨形态发生蛋白质15 多囊卵巢综合征 卵母细胞 转化生长因子Β 

分 类 号：R711.75[医药卫生—妇产科学]