嵌合体胚胎移植的临床研究现状  

Clinical Research Status of Mosaic Embryo Transfer

作　　者：闫惠惠 张云山(审校)[1] YAN Hui-hui;ZHANG Yun-shan(Reproductive Medicine Center,Tianjin Central Hospital of Gynecology Obstetrics,Tianjin 300100,China)

机构地区：[1]天津市中心妇产科医院生殖医学中心,300100

出　　处：《国际生殖健康／计划生育杂志》2023年第6期503-507,共5页Journal of International Reproductive Health/Family Planning

摘　　要：嵌合体胚胎是介于整倍体胚胎和非整倍体胚胎之间的第3种胚胎,是包含2种及2种以上遗传学不同细胞系的胚胎。随着遗传学技术的发展,二代测序技术对嵌合体胚胎的检出准确率更高。嵌合体胚胎移植结局的不确定性较高,着床失败率、流产率明显高于整倍体胚胎移植,对于能否移植嵌合体胚胎目前仍存在较大争议。但嵌合体胚胎移植为无整倍体胚胎的患者提供了生育可能性,因此,大样本和长期随访研究是未来研究的热点。尽管2017—2018年,中华医学会生殖医学分会发布了植入前遗传学诊断(preimplantation genetic diagnosis,PGD)/植入前遗传学筛查(preimplantation genetic screening,PGS)指南,但仍缺乏嵌合体胚胎移植的指导意见。综述目前嵌合体胚胎移植的研究现状,旨在为临床及相关科研提供借鉴。Mosaic embryo is the third type of embryo between euploid embryo and aneuploid embryo,which contains two or more genetically different cell lines.With the development of genetic technology,the next generation sequencing technology has a higher detection accuracy for mosaic embryos.The outcome of mosaic embryo transplantation is uncertain,and the rates of implantation failure and abortion are significantly higher than those of euploid embryo transplantation.There is still a great debate on whether mosaic embryo can be transferred.However,mosaic embryo transfer provides the possibility of fertility for patients with aneuploid embryos,so the studies with large sample and long-term follow-up will be the research hotspot.Although the Reproductive Medicine Branch of the Chinese Medical Association issued preimplantation genetic diagnosis/preimplantation genetic screening(PGD/PGS)guidelines in 2017-2018,there is still a lack of guidance on mosaic embryo transfer.This article reviews the current research status of mosaic embryo transfer.

关 键 词：嵌合体 胚胎移植 产前诊断 非整倍体 植入前遗传学检测 体外受精 

分 类 号：R714.8[医药卫生—妇产科学]