基于PI3K/AKT信号通路探讨益气化瘀法在糖尿病足溃疡中的应用  

Application of Yiqi Huayu Method in Diabetes Foot Ulcer Based on PI3K/AKT Signal Pathway

作　　者：陈仲件 杜娟娇[2] 张力[2] 王茜茜 郭夏晴 曹妍 CHEN Zhongjian;DU Juanjiao;ZHANG Li;WANG Xixi;GUO Xiaqing;CAO Yan(Graduate School of Guangxi University of Chinese Medicine,Nanning 530001,Guangxi,China;The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530001,Guangxi,China)

机构地区：[1]广西中医药大学研究生院,广西南宁530001 [2]广西中医药大学第一附属医院,广西南宁530001

出　　处：《实用中医内科杂志》2023年第10期6-9,共4页Journal of Practical Traditional Chinese Internal Medicine

基　　金：国家自然科学基金项目(81360572)。

摘　　要：糖尿病足溃疡(DFU)是最常见的难愈性创面之一,愈合周期长,严重影响患者生活质量。PI3K/AKT信号通路为人体内重要的信号通路,通过对机体肌肉、皮肤等组织的调节参与细胞凋亡、氧化应激、血管新生等生物学功能,促进创面的愈合。该病的病机可以总结为因虚感邪,邪气致瘀,瘀阻伤正,化腐致损,虚和瘀贯穿其中。以益气化瘀法治疗DFU患者,临床上取得良好疗效。基于PI3K/AKT信号通路探讨益气化瘀法在DFU中的应用,为DFU的防治提供参考及依据。Diabetic foot ulcer(DFU)is one of the most common complications of diabetes,with a long healing cycle and seri-ously affects the quality of life of patients.The PI3K/AKT signaling pathway is an important signaling pathway in the human body.Through the regulation of the bodys muscles,skin and other tissues,it participates in biological functions such as apopto-sis,oxidative stress and angiogenesis,and promotes the healing of wounds.The pathogenesis of this disease can be summarized as attacking by evils due to deficiency,blood stasis due to evils,blood stasis obstructing the body,damage due to decay and deficien-cy and blood stasis running through the whole course of the disease.The treatment of DFU patients with the method of supple-menting Qi and resolving blood stasis often achieves good clinical efficacy.This article explored the application of supplementing Qi and resolving blood stasis method in DFU based on the PI3K/AKT signaling pathway,providing reference and basis for the prevention and treatment of DFU.

关 键 词：PI3K/AKT信号通路 益气化瘀法 糖尿病足溃疡 

分 类 号：R269[医药卫生—中西医结合]