自拟通管汤治疗输卵管阻塞性不孕症的临床研究  

Clinical Study on Self-made Tongguan Decoction in Treating Tubal Obstructive Infertility

作　　者：孙建荣 汤丽丽 王爽 SUN Jianrong;TANG Lili;WANG Shuang(Nanyang Second Peoples Hospital,Nanyang 473009,Henan,China)

机构地区：[1]南阳市第二人民医院,河南南阳473009

出　　处：《实用中医内科杂志》2023年第9期49-52,共4页Journal of Practical Traditional Chinese Internal Medicine

基　　金：国家中医临床研究基地科研专项(2019JDZX098)。

摘　　要：目的 探究自拟通管汤治疗输卵管阻塞性不孕症的临床效果。方法 纳入2019年10月—2021年10月南阳市第二人民医院收治的78例输卵管阻塞性不孕症患者,以随机数字表法分为两组各39例。两组均行腹腔镜输卵管整形术治疗及常规干预,对照组口服桂枝茯苓丸,观察组应用自拟通管汤治疗,均治疗3个月经周期。比较治疗两组临床疗效;比较两组炎症因子水平[白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)];两组血液流变学指标[血浆黏度(PV)、红细胞聚集指数(AI)、红细胞沉降率(ESR)]。治疗结束后随访5个月,比较两组随访期间的妊娠情况。结果 治疗后,与对照组比较,观察组治疗总有效率高(P<0.05);治疗3个月经周期时,两组血清IL-6、IL-8、TNF-α水平均较治疗前降低,观察组均低于对照组(P<0.05);两组PV、AI、ESR均较治疗前降低,观察均低于对照组比较(P<0.05)。治疗后随访5个月,于对照组比较,观察宫内妊娠率高(P<0.05);两组间宫外妊娠率比较,差异无统计学意义(P>0.05)。结论 在常规治疗的基础上,将自拟通管汤应用于输输卵管阻塞性不孕症中可获得较好的临床疗效,能降低患者炎症因子水平,改善患者血液流变学指标,提高宫内妊娠率。Objective To explore the clinical effect of self-made Tongguan decoction in the treatment of Tubal Obstructive In-fertility.Methods From October 2019 to October 2021,78 patients with tubal obstructive infertility admitted to Nanyang Second Peoples Hospital were included in this prospective study and divided into two groups by random number table method,with 39 cases in each group.The two groups were treated with laparoscopic salpingoplasty and routine intervention.The control group was treated with Guizhi Fuling pill,and the observation group was treated with self-made Tongguan decoction.All of them were treated for 3 menstrual cycles.The clinical effects of the two groups were compared during 3 menstrual cycles.The levels of in-flammatory factors[interleukin-6(IL-6),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)]were compared between the two groups before treatment and during the three menstrual cycles of treatment.The hemorheological indexes[plas-ma viscosity(PV),erythrocyte aggregation index(AI),erythrocyte sedimentation rate(ESR)] of the two groups were com-pared before treatment and during the three menstrual cycles of treatment.After the treatment,the patients were followed up for 5 months,and the pregnancy of the two groups during the follow-up period was counted and compared.Results All the patients in the two groups successfully completed the trial,and there were no withdrawal cases.At the end of treatment,compared with the control group,the total effective rate of the observation group was higher,and the overall curative effect was better(P<0.05).The levels of serum IL-6,IL-8 and TNF-αin the two groups were lower than those in the control group after 3 men-strual cycles of treatment,and compared with the control group,the observation group was lower(P<0.05).PV,AI and ESR in the two groups were lower than those before treatment,and were lower than those in the control group(P<0.05).Compared with the control group,the intrauterine pregnancy rate was higher and the non-pregnancy rate was lower after

关 键 词：输卵管阻塞 输输卵管阻塞性不孕症 自拟通管汤 炎症因子 妊娠 

分 类 号：R271.14[医药卫生—中医妇科学]