干细胞膜片在骨与软骨修复中的应用  

Stem cells sheets for bone and cartilage repair

作　　者：马宏 邢飞[1] 项舟[1] 段鑫[1,2,3] MA Hong;XING Fei;XIANG Zhou;DUAN Xin(Department of Orthopedic Surgery,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,P.R.China;Department of Orthopedics,Gerontological Hospital of Sichuan Province,the Fifth People’s Hospital of Sichuan Province,Chengdu,Sichuan 610041,P.R.China;Department of Orthopedics,Ganzi Tibetan Autonomous Prefecture People’s Hospital,Ganzi,Sichuan 626000,P.R.China)

机构地区：[1]四川大学华西医院骨科,成都610041 [2]四川省老年医院/四川省第五人民医院骨科,成都610031 [3]甘孜藏族自治州人民医院骨科,四川甘孜626000

出　　处：《华西医学》2023年第10期1553-1558,共6页West China Medical Journal

基　　金：国家自然科学基金(82202705);四川省科学技术厅项目(2022YFS0099,2023NSFSC1738)。

摘　　要：细胞膜片技术是一种将细胞制备成片状的技术,该技术保留了大量的细胞外基质、细胞-细胞连接等,在骨软骨组织的修复与再生中具有广泛的应用前景。该文论述了干细胞膜片的种类、特性及构建方法,并对干细胞膜片血管化、与各种细胞因子和支架材料等复合应用于骨与软骨修复的研究现状进行了综述,旨在探索干细胞膜片在骨与软骨修复领域的进一步发展方向。Cell sheet technology refers to the preparation of cells into thin sheets,which retains a large amount of extracellular matrix,cell-cell junctions,and has a wide range of applications in the repair and regeneration of osteochondral tissues.This paper discusses the types,properties,and construction methods of stem cell sheets,and reviews the current research status of vascularization of stem cell sheets and their composite application with various cytokines and scaffolding materials for bone and cartilage repair,with the aim of exploring the direction of the further development of stem cell sheets in the field of bone and cartilage.

关 键 词：干细胞 细胞膜片 骨修复 软骨修复 组织工程 

分 类 号：R68[医药卫生—骨科学]