Furan Donor for NIR-II Molecular Fluorophores with Enhanced Bioimaging Performance  

作　　者：Chunchen Liu Mengfei Li Huilong Ma Zhubin Hu Xinyuan Wang Rui Ma Yingying Jiang Haitao Sun Shoujun Zhu Yongye Liang 

机构地区：[1]Department of Materials Science and Engineering,Shenzhen Key Laboratory of Printed Organic Electronics,Southern University of Science and Technology,Shenzhen 518055,China [2]State Key Laboratory of Supramolecular Structure and Materials,College of Chemistry,Jilin University,Changchun 130012,China [3]State Key Laboratory of Precision Spectroscopy,School of Physics and Electronic Science,East China Normal University,Shanghai 200241,China [4]Department of Chemistry and Bio-X,Stanford University,Stanford,CA 94305,USA [5]Collaborative Innovation Center of Extreme Optics,Shanxi University,Taiyuan,Shanxi 030006,China

出　　处：《Research》2023年第3期377-387,共11页研究（英文）

基　　金：the National Natural Science Foundation of China(Nos.21772084 and 12034008);Fundamental Research Layout of Shenzhen(No.JCY20180504165657443);Guangdong Provincial Natural Science Foundation-Yueshen Joint Funding(Youth Project)(No.2019A1515110464);the Shenzhen Science and Technology Commission-free exploration/general project(No.JCYJ20190812151209348);Special fund for local science and technology development guided by central government is acknowledged.The support from Shanghai Rising Star Program(No.21QA1402600);the graduate fellowship(201808440345)from Chinese Scholarship Council are also acknowledged.

摘　　要：The second near-infrared(NIR-II,1,000 to 1,700 nm)molecular fluorophores containing donor–acceptor–donor conjugated backbone have attracted substantial attention due to their outstanding advantages,such as stable emission and facilely tuned photophysical properties.However,it is still challenging for them to simultaneously achieve high brightness and red-shifted absorption and emission.Herein,furan is adopted as the D unit to construct NIR-II fluorophores,demonstrating red shift of absorption,enhanced absorption coefficient,and fluorescent quantum yield when compared with the generally used thiophene counterparts.The high brightness and desirable pharmacokinetics of the optimized fluorophore,IR-FFCHP,endows improved performance for angiography and tumor-targeting imaging.Furthermore,dual-NIR-II imaging of tumor and sentinel lymph nodes(LNs)has been achieved with IR-FFCHP and PbS/CdS quantum dots,enabling the in vivo imaging navigated LN surgery in tumor-bearing mice.This work demonstrates the potential of furan for constructing bright NIR-II fluorophores for biological imaging.

关 键 词：properties DONOR ABSORPTION 

分 类 号：O62[理学—有机化学]