运动调节骨源性因子改善阿尔茨海默病的机制  

Mechanism of Exercise Improving Alzheimer’s Disease via Regulating Bone-derived Factors

作　　者：徐帅 季泰 余锋[2] 谌晓安[1] XU Shuai;JI Tai;YU Feng;CHEN Xiao-An(School of Physical Education,Jishou University,Jishou 416000,China;School of Physical Education,Huaiyin Normal University,Huai’an 223300,China;Department of Physical Education,Shanghai Jiao Tong University,Shanghai 200240,China)

机构地区：[1]吉首大学体育科学学院,吉首416000 [2]淮阴师范学院体育学院,淮安223300 [3]上海交通大学体育系,上海200240

出　　处：《生物化学与生物物理进展》2023年第10期2305-2313,共9页Progress In Biochemistry and Biophysics

基　　金：国家民族体育重点研究基地开放基金(MZTY2205);湖南省哲学社会科学基金课题(19YBA283);江苏省教育科学十三五规划重点课题(T-a/2020/04);上海市哲学社会科学规划青年课题(2019ETY002);江苏省社会科学基金(22TYB005)资助项目。

摘　　要：阿尔茨海默病(Alzheimer’s disease,AD)作为一种神经退行性疾病会引起中枢神经病变。骨骼和大脑的紧密联系揭示出骨骼和AD之间的内在关联。骨骼作为骨内分泌器官逐渐受到重视。骨骼可分泌骨源性因子(SOST、OCN、OPN)、生成小胶质样细胞以及骨髓干细胞,这些骨源性因子和来源于骨骼的细胞通过血脑屏障调节大脑的生理特性,改善AD的代谢过程。运动刺激骨骼内分泌功能,调节骨源性因子分泌和表达水平,最终延缓AD病理变化并改善AD认知功能水平。本文侧重于阐述骨源性因子对AD的改善作用,以及运动刺激骨骼内分泌改善AD过程的新方法和新视角,为脑骨交互研究提供新思路。Alzheimer’s disease(AD)is a neurodegenerative disease that causes central neuropathy.The close association between bone and brain reveals an intrinsic link between bone and AD.Bone is gaining attention as a bone endocrine organ,which secretes osteogenic factors(SOST,OCN,OPN),and generates microglia and bone marrow stem cells.These Factors and cells derived from bone cross the blood-brain barrier and regulate the physiological properties of the brain,so then improve the metabolic process of AD.Exercise regulates skeletal endocrine function,increases the secretion and expression of bone-derived factors,and ultimately delays AD pathological changes and improves the level of AD cognitive function.This paper focuses on the ameliorative effects of bone-derived factors on AD,and new approaches and perspectives on exercise stimulation of skeletal secretion to improve the AD process,providing new ideas for brain-bone interaction studies.

关 键 词：运动干预 骨源性因子 内分泌 阿尔茨海默病 

分 类 号：Q5[生物学—生物化学]