环孢菌素A治疗再生障碍性贫血的临床疗效  

Clinical efficacy of cyclosporine A in the treatment of aplastic anemia

作　　者：徐娜[1] XU Na(Department of Hematology,Shenyang Red Cross Hospital,Shenyang,Liaoning,110013,China)

机构地区：[1]沈阳市红十字会医院血液科,辽宁沈阳110013

出　　处：《当代医学》2023年第12期20-23,共4页Contemporary Medicine

摘　　要：目的探究环孢菌素A治疗再生障碍性贫血的临床疗效。方法选取2020年1月至2021年3月本院收治的110例再生障碍性贫血患者作为研究对象,按照不同治疗方案分为对照组与治疗组,各55例。对照组在常规治疗基础上给予司坦唑醇药物治疗,治疗组在对照组基础上给予环孢菌素A药物治疗,比较两组临床疗效、不良反应发生情况及干预前后血常规指标、T细胞亚群水平。结果治疗组治疗总有效率为96.36%,高于对照组的83.64%,差异有统计学意义(P<0.05)。治疗组不良反应发生率为3.64%,低于对照组的14.55%,差异有统计学意义(P<0.05)。治疗前,两组中性粒细胞、血红蛋白、血小板水平比较差异无统计学意义;干预后,两组中性粒细胞、血红蛋白、血小板水平均高于治疗前,且治疗组高于对照组,差异有统计学意义(P<0.05)。干预前,两组CD3^(+)、CD4^(+)、CD8^(+)水平和CD4^(+)/CD8^(+)比较差异无统计学意义;干预后,两组CD3^(+)、CD4^(+)水平和CD4^(+)/CD8^(+)均高于治疗前,CD8^(+)水平均低于干预前,且治疗组CD3^(+)、CD4^(+)水平和CD4^(+)/CD8^(+)均高于对照组,CD8^(+)水平低于对照组,差异有统计学意义(P<0.05)。结论环孢菌素A药物联合司坦唑醇药物治疗再生障碍性贫血疗效确切,可有效改善患者自身血常规指标及T细胞亚群水平,值得临床推广应用。Objective To explore the clinical efficacy of cyclosporine A in the treatment of aplastic anemia.Methods A total of 110 patients with aplastic anemia admitted to our hospital from January 2020 to March 2021 were selected as the study subjects,and they were divided into the control group and the treatment group according to different treatment plans,with 55 cases in each group.The control group was treated with stazolol on the basis of conventional treatment,and the treatment group was treated with cyclosporine A on the basis of control group.The clinical efficacy,occurrence of adverse reactions,and blood routine indexes,and the level of T cell subsets before and after intervention were compared between the two groups.Results The total effective rate in the treatment group was 96.36%,which was higher than 83.64%in the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the treatment group was 3.64%,which was lower than 14.55%in the control group,and the difference was statistically significant(P<0.05).Before intervention,there were no significant differences in neutrophil,hemoglobin and platelet levels between the two groups;after intervention,the levels of neutrophil,hemoglobin and platelet of two groups were higher than before treatment,and the treatment group was higher than the control group,the differences were statistically significant(P<0.05).Before intervention,there were no significant differences in CD3^(+),CD4^(+),CD8^(+)levels and CD4^(+)/CD8^(+)between the two groups;after intervention,the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)of the two groups were higher than before intervention,and the levels of CD8^(+)were lower than before intervention,and the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the treatment group were higher than those in the control group,and the level of CD8^(+)was lower than that in the control group,the differences were statistically significant(P<0.05).Conclusion Cyclosporin A combined with stanzolol has definite effect

关 键 词：环孢菌素A 再生障碍性贫血 司坦唑醇 

分 类 号：R556.5[医药卫生—血液循环系统疾病]