特发性肺纤维化中医辨证客观化研究  

Objectification of TCM Syndrome Differentiation in Idiopathic Pulmonary Fibrosis

作　　者：杨丽[1] 刘勇明[1] 盛野 庞立健[1] 焦蕊[1] 王天娇 吕晓东[2] YANG Li;LIU Yongming;SHENG Ye;PANG Lijian;JIAO Rui;WANG Tianjiao;LÜXiaodong(Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China;Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China)

机构地区：[1]辽宁中医药大学附属医院,辽宁沈阳110032 [2]辽宁中医药大学,辽宁沈阳110847

出　　处：《中华中医药学刊》2023年第9期58-62,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(82274440,82204993);辽宁省科学技术计划项目(2019-ZD-0962);辽宁省中医药特色人才培养项目(辽中医药综合字[2021]38号);辽宁省教育厅青年科技人才“育苗”项目(L202029);辽宁中医药大学自然科学类重点项目(2021LZY040)。

摘　　要：特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)发病率逐年上升,致病因素复杂、致死率极高,已然成为严重影响我国人口健康的慢性复杂性疾病。大量循证依据表明中医药在改善IPF症状、提高IPF生存质量和减少急性加重次数方面发挥独特优势,IPF辨证论治逐渐在临床应用中得到高度认可,IPF中医辨证客观化不仅有利于提高中医诊治水平,而且为中医药标准化、规范化研究提供基础。目前IPF中医辨证客观化仍存在辨证分型方法不统一,有迹可循的中医证候相关研究严重不足,将现代医学指标、组学技术与IPF中医证候相结合在整体水平上探讨其特异性微观特征,对于推动中医证候学和微观辨证学发展意义重大。该研究综述近年来IPF辨证分型方法以及寻找IPF不同中医证型间的现代化指标差异,将胸部高分辨计算机X线断层扫描、血液学检查、动脉血气分析、肺功能检测、基因转录组学、蛋白质组学、代谢组学等指标引入IPF中医辨证客观化研究,运用现代化技术探索IPF患者不同证型之间的潜在生物标志物,旨在深入探讨IPF不同中医证型的致病机制,以期为中医药辨证治疗IPF提供客观量化指标和循证参考依据。The incidence rate of idiopathic pulmonary fibrosis(IPF)is increasing,with complex pathogenic factors and high mortality.It has become a chronic complex disease.Extensive evidence-based medicine shows that traditional Chinese medicine(TCM)in the treatment of IPF has unique advantages in improving symptoms and quality of life,reducing frequence of acute exacerbation.Syndrome differentiation and treatment of IPF has gradually been highly recognized in clinical application.The objectification of TCM syndrome differentiation is not only conducive to improving the level of TCM diagnosis and treatment,but also provides the basis for the standardization of TCM.At present,the objectification of TCM syndrome differentiation in IPF still has inconsistent methods of syndrome differentiation and classification,and lack of relevant research on traceable TCM syndromes.It is of great significance to combine modern medical indicators,omics technology and IPF TCM syndromes to explore their specific microscopic characteristics at the overall level for promoting the development of TCM syndromes and microscopic syndrome differentiation.This study summarizes the methods of syndrome differentiation and classification of IPF in recent years and the modern indicator differences between different TCM syndrome types of IPF.It introduced high-resolution computed X-ray tomography,hematology examination,arterial blood gas analysis,pulmonary function test,gene transcriptomics,proteomics,metabolomics into the objective study of TCM syndrome differentiation of IPF,and used modern technology to explore the potential biomarkers between different syndrome types of IPF patients,aiming to deeply explore the pathogenic mechanism of different TCM syndrome types of IPF,in order to provide objective quantitative indicators and evidence-based reference for TCM syndrome differentiation and treatment of IPF.

关 键 词：特发性肺纤维化 辨证论治 标准化 客观化 组学技术 

分 类 号：R256.1[医药卫生—中医内科学]