中西医结合治疗脾胃虚寒型慢性浅表性胃炎疗效及对外周血胃肠激素、T淋巴细胞亚群、IL-8、IL-32、MCP-1的影响  

Effect of Modified Huangqi Jianzhong Decoction(加味黄芪建中汤)Combined with Esomeprazole on Peripheral Blood Gastrointestinal Hormones,T Lymphocyte Subsets,IL-8,IL-32,MCP-1 and Prognosis in Patients with Chronic Superficial Gastritis Due to Deficiency of Spleen and Stomach

作　　者：严红梅[1] 代琳[1] 许丹[1] 余首德[1] 黄超群[1] 许话 常城 刘惠武[1] YAN Hongmei;DAI Lin;XU Dan;YU Shoude;HUANG Chaoqun;XU Hua;CHANG Cheng;LIU Huiwu(Wuhan Hospital of Traditional Chinese Medicine,Wuhan 430014,Hubei,China)

机构地区：[1]武汉市中医医院,湖北武汉430014

出　　处：《中华中医药学刊》2023年第9期156-159,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家中医药管理局全国名老中医药专家传承工作室项目(国中医药人教函[2018]134);武汉市卫健委刘惠武武汉中医名师工作室项目(武卫[2019]17)。

摘　　要：目的探讨加味黄芪建中汤联合艾司奥美拉唑治疗脾胃虚寒型慢性浅表性胃炎(chronic superficial gastritis,GAS)的效果。方法选择2019年10月—2021年5月收治的190例脾胃虚寒型慢性浅表性胃炎患者进行研究,使用随机数字表将其分为试验组和对照组,每组95例,对照组接受艾司奥美拉唑治疗,试验组接受加味黄芪建中汤联合艾司奥美拉唑治疗,共治疗8周,比较两组外周血胃肠激素、T淋巴细胞亚群、白细胞介素(interleukin,IL)-8、IL-32、单核细胞趋化因子-1(monocyte chemotactic protein 1,MCP-1)水平,比较两组治疗前后中医证候积分以及中医证候疗效。结果治疗后试验组胃动力素(motilin,MTL)、CD_(3)^(+)、CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)水平均高于对照组,差异具有统计学意义(P<0.05),试验组慢性浅表性胃炎、P物质(SP)、CD_(8)^(+)、IL-8、IL-32、MCP-1以及中医证候积分均低于对照组,差异具有统计学意义(P<0.05),试验组中医证候疗效优于对照组,差异具有统计学意义(P<0.05)。结论加味黄芪建中汤联合艾司奥美拉唑治疗脾胃虚寒型慢性浅表性胃炎具有确切的疗效,可有效调节胃肠激素的分泌,改善免疫功能,抑制炎症反应,适合在临床推广应用。Objective To investigate the effect of Modified Huangqi Jianzhong Decoction(加味黄芪建中汤)combined with es-omeprazole in the treatment of chronic superficial gastritis with deficiency of spleen and stomach.Methods A total of 190 patients with chronic superficial gastritis of deficiency of spleen and stomach type admitted in the hospital from October 2019 to May 2021 were selected for study,and they were divided into experimental group and control group using a random number table,95 cases in each group.The control group received esomeprazole and the experimental group received Modified Huangqi Jianzhong Decoction combined with esomeprazole for a total of 8 weeks.The levels of peripheral blood gastrointestinal hormones,T lymphocyte subsets and interleukin-8(IL-8),interleukin-32(IL-32)and chemokine-1(MCP-1)were compared between the two group sand the TCM syndrome scores and the efficacy of TCM syndromes were compared between the two groups before and after treatment.Results After treatment,the levels of motilin(MTL),CD_(3)^(+),CD_(4)^(+) and CD_(4)^(+)/CD_(8)^(+) in the experimental group were higher than those in the control group,and the difference was statistically significant(P<0.05).And TCM syndrome scores were lower than those in the control group and the difference was statistically significant(P<0.05).Conclusion Modified Huangqi Jianzhong Decoction combined with esomeprazole has a definite curative effect in the treatment of chronic superficial gastritis due to deficiency of spleen and stomach,and can effectively regulate the secretion of gastrointestinal hormones,improve the immune function and in-hibit the inflammatory response,and is suitable for clinical application.

关 键 词：黄芪建中汤 艾司奥美拉唑 脾胃虚寒型慢性浅表性胃炎 T淋巴细胞亚群 趋化因子-1 中医证候积分 

分 类 号：R256.3[医药卫生—中医内科学]