活血养阴方治疗肾虚夹瘀型IgA肾病临床疗效及对肾功能、炎症水平以及氧化应激的影响  

Clinical Effect of Huoxue Yangyin Prescription(活血养阴方)on IgA Nephropathy Patients with Kidney Deficiency and Blood Stasis and Its Effect on Renal Function,Inflammation Level and Oxidative Stress

作　　者：沈岚[1] 张之蕙[1] 费梅[1] SHEN Lan;ZHANG Zhihui;FEI Mei(The First Affiliated Hospital of Soochow University,Suzhou 215006,Jiangsu,China)

机构地区：[1]苏州大学附属第一医院,江苏苏州215006

出　　处：《中华中医药学刊》2023年第9期243-247,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：江苏省中医药科技发展计划项目(YB2020101)。

摘　　要：目的观察活血养阴方治疗肾虚夹瘀型IgA肾病患者的临床疗效及其对肾功能、炎症水平以及氧化应激的影响。方法选择2019年6月—2022年6月到苏州大学附属第一医院就诊的70例IgA肾病患者,按照自愿原则分为常规治疗组和活血养阴组各35例,常规治疗组患者给予西医常规治疗;活血养阴组在常规治疗组的基础上予以活血养阴方治疗。观察两组患者的临床疗效和中医证候改善情况,并比较干预前、后患者的炎症和氧化应激指标水平的变化。结果常规治疗组的有效率为71.42%(25/35),活血养阴组的有效率为91.42%(32/35),活血养阴组的有效率明显优于常规治疗组(P<0.05)。给药完成后,活血养阴组的血尿素氮(BUN)、血肌酐(SCr)、血尿酸(UA)、24 h尿蛋白以及尿红细胞等肾功能指标水平相较于常规治疗组均明显下降(P<0.05,P<0.01)。给药完成后,活血养阴组面色无华或晦暗、腰酸乏力、定位刺痛以及口干唇燥等主要证候评分水平相较于常规治疗组显著下降(P<0.001)。给药完成后,与常规治疗组比较,活血养阴组的丙二醛(MDA)含量明显减少(P<0.05),而超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-PX)含量均明显增加(P<0.05)。给药前两组患者血清中单核细胞趋化因子-1(MCP-1)、肿瘤坏死因子-α(TNF-α)以及白介素-6(IL-6)水平差异无统计学意义(P>0.05)。给药完成后,相较于常规治疗组,活血养阴组血清中MCP-1、TNF-α以及IL-6含量明显减少(P<0.05)。结论活血养阴方联合西医常规治疗能够改善IgA肾病患者的肾功能,减轻临床证候,其作用机制与该药能够抑制炎症和氧化应激水平有关。Objective To observe the clinical efficacy of Huoxue Yangyin Prescription(活血养阴方)in the treatment of IgA nephropathy patients with kidney deficiency and blood stasis and its effect on renal function,inflammation level and oxidative stress.Methods A total of 70 patients with IgA nephropathy who visited the First Affiliated Hospital of Sooksu University from June 2019 to June 2022 were selected and divided into conventional treatment group and invigorating blood and nourishing Yin group according to the principle of voluntaneity.The conventional treatment group received conventional treatment of Western medicine.The invigorating blood and nourishing Yin group was treated with Huoxue Yangyin Prescription on the basis of conven-tional treatment.The clinical efficacy and improvement of TCM syndromes were observed in the two groups,and the changes of inflammatory and oxidative stress indexes were compared before and after intervention.Results The effective rate of the conven-tional treatment group was 71.42%(25/35)and that of the activating blood and nourishing Yin group was 91.42%(32/35).The effective rate of the activating blood and nourishing Yin group was significantly better than that of the conventional treatment group(P<0.05).After drug administration,the levels of blood urea nitrogen(BUN),serum creatinine(SCr),urine acid(UA),24 h urine protein and urine red blood cell levels in the activating blood and nourishing Yin group were decreased significantly compared with those in the conventional treatment group(P<0.05,P<0.001).After drug administration,the main symptoms scores of the patients in the activating blood and nourishing Yin group group were significantly lower than those in the convention-al treatment group(P<0.01),such as pale or dull face,weak waist,positioning pain and dry mouth and dry lips.After drug ad-ministration,compared with those in the conventional treatment group,malondialdehyde(MDA)content in activating blood and nourishing Yin group decreased significantly,while the contents of sup

关 键 词：活血养阴方 IGA肾病 肾功能 临床疗效 炎症水平 氧化应激 

分 类 号：R256.5[医药卫生—中医内科学]