血浆FIB、CK-MB在冠心病患者中的表达及临床意义  

The Expression and Clinical Significance of Plasma FIB and CK-MB in Patients with Coronary Heart Disease

作　　者：王瑞红[1] 葛廷[1] WANG Rui-hong;GE Ting(The First People's Hospital of Xinxiang City,Henan Province,453000)

机构地区：[1]河南省新乡市第一人民医院,河南新乡453000

出　　处：《航空航天医学杂志》2023年第9期1028-1031,共4页Journal of Aerospace medicine

摘　　要：目的 观察血浆纤维蛋白原(FIB)、肌酸激酶同工酶(CK-MB)在冠心病患者中的表达,并分析血浆FIB、CK-MD与冠心病患者冠状动脉狭窄程度的关系。方法 入选2021年03月-2023年02月收治的92例冠心病患者作为研究对象,所有患者均行冠状动脉造影检查,根据Gensini评估冠状动脉病变程度,分为轻症组、中症组、重症组,入院当天检测患者血浆FIB、CK-MB水平,询问并记录患者基本资料,根据检查结果,分析血浆FIB、CK-MB水平与冠心病患者冠状动脉狭窄程度的关系。结果 纳入的92例冠心病患者,血浆FIB检测结果为3.75±0.67(g/L),血浆CK-MB检测结果为21.36±3.26(IU/L)。经冠状动脉造影检查,92例患者冠状动脉轻度狭窄28例、中度狭窄40例、重度狭窄24例。重症组多支病变比例高于轻症组和中症组,中症组多支病变比例高于轻症组,差异有统计学意义(P<0.05);重症组血浆FIB、CK-MB水平均高于中症组、轻症组,中症组水平均高于轻症组,差异有统计学意义(P<0.05)。经Kendall′s tau-b相关系数检验显示,血浆FIB、CK-MB水平与冠心病患者冠状动脉狭窄程度呈正相关(r>0,P<0.05)。采用有序回归检验,冠心病患者血浆FIB、CK-MB表达上调是导致冠状动脉重度狭窄的影响因素(P<0.05)。结论 血浆FIB、CK-MB水平与冠心病患者冠状动脉狭窄程度呈正相关,血浆FIB、CK-MB表达上调导致冠心病患者冠状动脉狭窄程度加重。Objective To observe the expression of plasma fibrinogen(FIB)and creatine kinase isoenzyme(CK-MB)in patients with coronary heart disease,and to analyze the relationship between plasma FIB and CK-MD and the degree of coronary artery stenosis in patients with coronary heart disease.Methods 92 patients with coronary heart disease admitted from March 2021 to February 2023 were selected as the study objects.All patients underwent coronary angiography,and were divided into mild,moderate and severe groups according to Gensini assessment of the degree of coronary artery disease.Plasma FIB and CK-MB levels were detected on the day of admission.The basic data of patients were inquired and recorded.According to the examination results,the relationship between plasma FIB and CK-MB levels and the degree of coronary artery stenosis in patients with CHD was analyzed.Results In 92 patients with coronary heart disease,plasma FIB and CK-MB were 3.75±0.67(g/L)and 21.36±3.26(IU/L)respectively.By coronary angiography,28 of the 92 patients had mild coronary artery stenosis,40 had moderate stenosis,and 24 had severe coronary artery stenosis.The proportion of multi-vessel lesions in severe group was higher than that in mild group and moderate group,and the proportion of multi-vessel lesions in moderate group was higher than that in mild group,the difference was statistically significant(P<0.05).The levels of plasma FIB and CK-MB in severe group were higher than those in moderate and mild disease group,and the levels in moderate disease group were higher than those in mild disease group,the difference was statistically significant(P<0.05).Kendall's tau-b correlation coefficient test showed that plasma FIB and CK-MB levels were positively correlated with the degree of coronary artery stenosis in CHD patients(r>0,P<0.05).According to the ordered regression test,the up-regulated expression of plasma FIB and CK-MB in CHD patients was the influential factor leading to severe coronary artery stenosis(P<0.05).Conclusions The levels of plasma

关 键 词：冠心病 纤维蛋白原 肌酸激酶同工酶 冠状动脉狭窄程度 

分 类 号：R541.4[医药卫生—心血管疾病]