环状RNA在肺动脉高压中的研究进展  

Research progress in the role of circRNAs in pulmonary hypertension

作　　者：黄殊伦 唐昊 吴艳 HUANG Shulun;TANG Hao;WU Yan(Department of Respiratory and Critical Care Medicine,Wuxi People's Hospital,Wuxi People's Hospital Affiliated to Nanjing Medical University,Wuxi,Jiangsu 214000,China)

机构地区：[1]无锡市人民医院、南京医科大学附属无锡人民医院呼吸与危重症医学科,江苏无锡214000

出　　处：《安徽医药》2023年第12期2333-2338,共6页Anhui Medical and Pharmaceutical Journal

基　　金：国家自然科学基金(82173472)。

摘　　要：环状RNA是一种稳定、保守的凭借共价键首尾相连的闭合环状RNA,研究表明环状RNA和多种疾病的发生发展密切相关。肺动脉高压(PH)是一类以肺血管阻力进行性升高为特征的肺血管疾病,其发病机制尚不明确。近年来越来越多的研究提示环状RNA在PH的发生发展中可能扮演重要角色,为PH的诊断和治疗提供新线索。该文结合环状RNA在PH领域的研究现状,综述其在PH中的作用和机制。Circular RNA(circRNA)is a type of stable and conserved RNA molecular with covalently closed loop structures.Several recent studies have shown that circRNA is closely related to the occurrence and development of multiple diseases.Pulmonary hypertension is a kind of pulmonary vascular disease characterized by a progressive increase of pulmonary vascular resistance.However,its pathogenesis is still not clear.In recent years,researchers have found that circRNA may play a significant role in the occurrence and development of pulmonary hypertension,which provides new clues for the diagnosis and treatment of pulmonary hypertension.In this review,we elaborate on the mechanism of circRNAs in pulmonary hypertension,based on the research status of circRNAs in pulmonary hypertension.

关 键 词：DNA 环状 肺动脉高压 肺动脉平滑肌细胞 肺动脉内皮细胞 细胞焦亡 

分 类 号：R544.1[医药卫生—心血管疾病]