IL-18和IL-37b对naive CD4^(+)T细胞分化的影响及其在哮喘中的作用研究进展  

Research progress of IL-18 and IL-37b in naive CD4^(+)T differentiation of patients with allergic asthma

作　　者：王君灵 湛萌萌 谷芳秋 张钊龙 王思勤 何韶衡 WANG Junling;ZHAN Mengmeng;GU Fangqiu;ZHANG Zhaolong;WANG Siqin;HE Shaoheng(Department of Allergy,Henan Provincial People's Hospital,Zhengzhou University People's Hospital,Zhengzhou 450003,China;Allergy and Clinical Immunology Research Centre,the First Affiliated Hospital of Jinzhou Medical University,Jinzhou 121001,China;不详)

机构地区：[1]郑州大学人民医院、河南省人民医院过敏反应科,郑州450003 [2]锦州医科大学附属第一医院变态反应与临床免疫研究中心,辽宁锦州121001

出　　处：《实用医学杂志》2023年第20期2683-2686,共4页The Journal of Practical Medicine

基　　金：国家自然科学基金项目(编号:81471592);河南省重点研发与推广专项(编号:232102311022);博士后科研启动基金项目(编号:HN2022097,ZC20230003);辽宁省自然科学基金项目(编号:2019-ZD-0801,LJKZ0796);锦州医科大学博泽青年科技人才托举基金项目(编号:JYBZQT2110)。

摘　　要：过敏性哮喘(allergic asthma,AA)是呼吸系统最常见的过敏性疾病之一,CD4^(+)T细胞相关亚型在AA发病中起重要作用。白细胞介素(IL)-18和IL-37b通过与IL-18Rα结合调控naive CD4^(+)T细胞的分化进而在AA中起拮抗作用。鉴于此,了解IL-18和IL-37b在AA naive CD4^(+)T细胞分化中的作用对于AA的病机、诊疗及其相关生物制剂的研发具有重要意义。Allergic asthma(AA)is one of the most common allergic respiratory diseases.CD4^(+)T cell subtypes play an important role in the pathogenesis of AA.IL-18 and IL-37b are involved in the pathogenesis of AA via binding to IL-18Rαand thus regulating the differentiation of naive CD4^(+)T cells.In view of this,understanding the role of IL-18 and IL-37b in the differentiation of naive CD4^(+)T cells in AA is of great significance for the pathogenesis,diagnosis and treatment of AA,and for the research and development of biological agents.

关 键 词：过敏性哮喘 naive CD4^(+)T细胞 白细胞介素-18 白细胞介素-37b 

分 类 号：R392.8[医药卫生—免疫学]