参考全同胞数量在同胞鉴定中的意义  

The significance of the number of reference full ibling in sibship analysis

作　　者：黄健[1,2] 蔡金洪[1,2] 郝伟琪[1,2] Huang Jian;Cai Jinhong;Hao Weiqi(Department of forensic genetics,Brain Hospital of Hunan Province,The Second People's Hospital of Hunan Province,Changsha 410007,China;Hunan university of Chinese Medicine,Changsha 410007,China)

机构地区：[1]湖南省脑科医院(湖南省第二人民医院)法医物证科,湖南长沙410007 [2]湖南中医药大学,湖南长沙410007

出　　处：《中国法医学杂志》2023年第5期516-519,共4页Chinese Journal of Forensic Medicine

摘　　要：目前全同胞鉴定多建立在可疑同胞与一名参考个体之间,然而两名个体之间的亲缘鉴定信息量有限、识别力低。同胞鉴定时,常常有不止一个参考同胞,如果多名参考个体作为一个整体,基因信息被充分利用,判定的识别力将极大提高。本文通过对一名参考同胞和多名参考同胞在鉴定中识别能力的比较,同时阐述多名参考同胞的父母基因型重构及同胞鉴定似然率计算,证明多名参考个体在亲缘鉴定中具有一名参考个体不能比拟的优势:在检测相同数量基因座的情况下能极大提高鉴定结果的可靠性。同胞鉴定中,充分利用可参考个体信息具有重要意义。At present,sibship is mostly established between two individuals.Nevertheless,the information obtained by the pair-wise likelihood approaches are limit and the discrimination is low.Frequently,there is more than one reference sibling available in sibship analysis.If multiple reference individuals are taken as a whole and the genetic information is fully utilized,the discrimination power is expected to improve dramatically.Aiming to explain the value and necessary of multiple reference siblings in sibship estimation,the discrimination power of one reference sibling and multiple reference siblings was compared,and the method for analysis of the probabilities of reconstructed parents and the likelihood ratio of sibship were described.It is of great significance to make full use of the information of reference siblings in sibship analysis.

关 键 词：法医物证学 同胞鉴定 参考同胞 识别力 似然率 

分 类 号：D919.4[医药卫生—法医学]