污水分析中直接进样法与固相萃取法的比较与应用  

Comparison and application of the direct injection method and solid phase extraction method in wastewater toxicology monitoring

作　　者：原帅 任航 骆如欣 向平 Yuan Shuai;Ren Hang;Luo Ruxin;Xiang Ping(Shanghai Key Laboratory of Forensic Medicine,Shanghai Forensic Service Plaform,Institute of Forensic Science,Ministry of Justice,PRC,Shanghai 200063,China;School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China)

机构地区：[1]司法鉴定科学研究院,上海市法医学重点实验室,上海市司法鉴定专业技术服务平台,司法部司法鉴定重点实验室,上海200063 [2]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《中国法医学杂志》2023年第5期559-565,共7页Chinese Journal of Forensic Medicine

基　　金：“十四五”国家重点研发计划资助项目(2022YFC3300903);中央级科研院所基本科研业务费资助项目(GY2018Z-2);上海市法医学重点实验室资助项目(21DZ2270800);上海市司法鉴定专业技术服务平台资助项目(19DZ2292700)。

摘　　要：目的 将本课题组最新研发的测定污水中11种常见毒品及其代谢物的直接进样法与本课题组已发表固相萃取法的定量结果进行比较,以保证直接进样法定量结果的准确性,并对当前常见的污水前处理方法进行比较及应用探究。方法 选取3份已知浓度的添加污水样品及15份未知浓度的实际污水样品,使用两种方法进行样品前处理,并将检测到的相同目标物浓度之间的差异百分比进行计算。结果 两种方法的差异百分比范围为-13.76%~14.00%,这一差异值可被接受。结论 直接进样法可得到良好的定量结果并能满足污水分析的高通量分析要求,同时建议各实验室开发两种污水处理方法,对司法部门加快建设高水平的毒品实验室体系,推进禁毒科技创新具有重要意义。Objective To compare the quantitative results of the solid phase extraction method with the recently developed direct injection method,both published by our research group,in determination of 11 common drugs and their metabolites in wastewater,so as to ensure the accuracy of the quantitative results by the direct injection method,and to compare the current common wastewater pretreatment methods.Methods Three samples of additive wastewater with known concentrations and 15 samples of actual wastewater with unknown concentrations were involved,and the quantitative results of the two methods were compared.Results The percent differences between the two methods ranged from-13.76%to 14.00%,which were acceptable.Conclusion The direct injection method can obtain good quantitative results and meet the current requirements of high-throughput analysis for wastewater analysis.It is suggested that each laboratory should develop two wastewater treatment methods at the same time,which is of great significance for the judicial department to accelerate the construction of a high-level drug laboratory system and promote the innovation of anti-drug science and technology.

关 键 词：污水分析 滥用药物 定量结果比较 应用探究 

分 类 号：D918.93[政治法律—法学]