血清差异性表达分子在机械性窒息死因鉴定中的作用  

Differentially expressed molecules in serum and its significance in the authentication of death from mechanica asphyxial

作　　者：施翌 胡毅恺 马开军 陈龙[1] Shi Yi;Hu Yikai;Ma Kaijun;Chen Long(Department of Forensic Medicine,School of Basic Medical Sciences,Fudan University,Shanghai 200032;Shanghai Institute of Forensic Science,Public Security Bureau,Shanghai Key Laboratory of Crime Scene Evidence,Shanghai 200082)

机构地区：[1]复旦大学基础医学院法医学系,上海200032 [2]上海市公安局物证鉴定中心,上海市现场物证重点实验室,上海200082

出　　处：《中国法医学杂志》2023年第5期566-571,共6页Chinese Journal of Forensic Medicine

基　　金：国家自然科学基金面上资助项目,机械性窒息死亡特异性标志物的鉴定及其机制研究(81971788);上海市刑事科学技术研究院现场物证重点实验室开放课题,机械性窒息死亡死因快速鉴定体系及其应用研究(2021XCWZK09)。

摘　　要：血清是血液的重要组成部分,其成分变化可直接反映机体内环境的变化。在对缺氧性疾病的研究中,有学者提出血清差异性表达分子可作为疾病的诊断标志物。由于缺乏特异性的诊断指标,机械性窒息死亡的精准死因鉴定至今仍是法医病理学鉴定的难点。本文回顾了缺氧相关疾病中的血清差异性表达分子的研究,并讨论了这些分子用于机械性窒息死亡鉴定的可能性,以期为机械性窒息精准死因鉴定研究提供新思路。Serum is an important component of blood,whose composition may vary as the internal environment changes.It has been reported that differentially expressed molecules in serum may serve as biomarkers in many hypoxiarelated diseases.Due to the lack of specific diagnostic biomarkers,the precise authentication of death from mechanical asphyxia(DMA)is still a vital issue in forensic pathology practice.This article reviewed the differentially expressed molecules of hypoxia-related diseases in serum and discussed the possibility of applying these molecules on DMA authentication,which may provide a new idea for precise authentication of DMA.

关 键 词：法医病理学 血清 缺氧 机械性窒息 生物标志物 

分 类 号：D919.1[医药卫生—法医学]