人工晶体开孔孔径对晶体变形及前房内流场影响的数值模拟研究  

Effects of Hole Sizes on Implantable Collamer Lens Deformation and Flow Field in Anterior Chamber:A Numerical Simulation Study

作　　者：高乐 尹海国[1] 蒋慧莉 崔海航[1] 陈力 马波 吴利安 GAO Le;YIN Haiguo;JIANG Huili;CUI Haihang;CHEN Li;MA Bo;WU Li’an(School of Building Services Science and Engineering,Xi’an University of Architecture and Technology,Xi’an 710055,China;Department of Ophtalmology,Xi’an People’s Hospital(Xi’an Fourth Hospital),Shaanxi Provincial Eye Hospital,Xi’an 710004,China)

机构地区：[1]西安建筑科技大学建筑设备科学与工程学院,西安710055 [2]西安市人民医院(西安市第四医院)陕西省眼科医院眼科,西安710004

出　　处：《医用生物力学》2023年第4期690-696,共7页Journal of Medical Biomechanics

基　　金：西安市创新能力强基计划-医学研究项目(21YXYJ0047)。

摘　　要：目的研究不同人工晶体(implantable collamer lens,ICL)开孔孔径对晶体变形和前房内流场的影响。方法从医工结合角度出发,采用流固耦合数值模拟方法,研究人工晶体不同开孔孔径对其变形及眼内房水流场(流量、速度场、压力场、温度场)的影响。结果流体动力学方面,房水通过ICL中央孔的房水流量从大到小对应的孔径依次为0.36、0.40、0.30、0.20、0.10 mm,该流量与孔径呈非线性关系。后房压力略高于前房,前后房压差随孔径增大逐渐降低。眼内温度分布对孔径的影响并不敏感。固体静力学方面,0.36 mm孔径的ICL变形量最小,其变形量受房水通过中央孔的流量所主导,该流量越大,ICL的变形越小。结论本文综合流体动力学和固体静力学分析,验证了现有0.36 mm孔径的合理性,并提出理想的孔径范围为d≥0.36 mm。研究结果有助于探明ICL的失效机制,提高临床手术的成功率,为未来人工晶体的国产化提供经验。Objective To study the effects of different hole sizes on implantable collamer lens(ICL)deformation and flow field in anterior chamber.Methods From the perspective of the combination of medicine and engineering,the fluid-structure coupling numerical simulation method was adopted to study the influence of different hole sizes of ICL on its deformation and intraocular aqueous humor flow field(mass flow,velocity,pressure and temperature).Results In terms of fluid dynamics,the hole sizes for aqueous humor flowing through the central hole of ICL from large to small was 0.36,0.40,0.30,0.20,0.10 mm,respectively,and such flow showed a nonlinear relationship with hole sizes.The pressure of posterior chamber was slightly higher than that of anterior chamber,and the pressure difference between anterior and posterior chambers gradually decreased with the increase of hole sizes.The temperature distribution in the eye was not sensitive to the effect of hole sizes.In terms of solid statics,the ICL with the diameter of 0.36 mm had the smallest deformation,and its deformation was dominated by the flow of aqueous humor through the central hole.The larger the flow rate,the smaller the ICL deformation.Conclusions Through comprehensive analysis of fluid dynamics and solid statics,this study verified the rationality of the existing 0.36 mm hole size,and proposed that an ideal hole size range should be d≥0.36 mm.The results are helpful to explore the failure mechanism of ICL,improve the success rate of clinical surgery,and provide experience for ICL localization in the future.

关 键 词：人工晶体 房水 流固耦合 数值模拟 医工结合 

分 类 号：R318.01[医药卫生—生物医学工程]