胃肠吻合钉织构表面对细胞外液流速与剪切力的影响  

Effects of Texture Surface of Gastrointestinal Staples on Extracellular Fluid Velocity and Shear Force

作　　者：马言 郑清春 张春秋[1,2] 张曌雄 付蔚华[3] 胡亚辉 MA Yan;ZHENG Qingchun;ZHANG Chunqiu;ZHANG Zhaoxiong;FU Weihua;HU Yahui(Tianjin Key Laboratory of the Design and Intelligent Control of the Advanced Mechatronical System,Tianjin 300384,China;National Demonstration Center for Experimental Mechanical and Electrical Engineering Education(Tianjin University of Technology),Tianjin 300384,China;Department of Gastrointestinal and Anorectal Surgery,General Hospital of Tianjin Medical University,Tianjin 300052,China)

机构地区：[1]天津市先进机电系统设计与智能控制重点实验室,天津300384 [2]机电工程国家级实验教学示范中心(天津理工大学),天津300384 [3]天津医科大学总医院胃肠肛肠外科,天津300052

出　　处：《医用生物力学》2023年第4期817-823,共7页Journal of Medical Biomechanics

基　　金：国家自然科学基金项目(11672208,81741141);天津市医学重点学科(专科)建设项目(TJSYXZDXK015303078101015);天津市科技特派员项目(22YDTPJC00400)。

摘　　要：目的研究胃肠微环境中的吻合钉表面微织构的几何参数变化对细胞外液流速与壁面处剪切力的影响规律,为吻合钉织构化表面对细胞黏附的促进作用提供理论依据。方法将吻合钉表面微织构结构引入到平板流动腔底面,应用ANSYS Fluent建立平板流动腔的二维模型并进行网格划分,研究不同高度、边长、间距参数的织构化底面的平板流动腔中细胞外液流速与壁面处剪切力数值,并对数据进行处理分析。结果吻合钉表面微织构的引入增强了平板流动腔内细胞外液的流速,且合适的微织构几何参数的引入可以增大微织构微脊处的壁面处剪切力。微凹坑内的细胞外液流速较低且会形成漩涡,微织构高度、间距的增加以及边长的减小可以增强微凹坑内漩涡的强度。结论通过控制微织构的参数可以改变细胞外液流速与壁面处剪切力,进而促进细胞的黏附。Objective To study the effect of geometric parameters of micro-texture on the surface of staples in gastrointestinal microenvironment on extracellular fluid velocity and wall shear force,so as to provide theoretical references for promotion of the textured surface of staples on cell adhesion.Methods The micro-texture structure on the surface of staples was introduced into the bottom surface of flat plate flow chamber.The twodimensional(2D)model of flat plate flow chamber was established by ANSYS fluent and meshed.In gastrointestinal microenvironment,the extracellular velocity and wall shear force of flat plate flow chamber with different height,side length and spacing parameters were simulated,and the data were processed and analyzed.Results The introduction of micro-texture on the surface of staples enhanced the flow velocity in plate flow chamber,and the appropriate geometric parameters of micro-texture could increase wall shear force at the microridge of micro-texture.The extracellular fluid velocity in micro-pits was low and vortices would be formed.The increase in micro-texture height,spacing and the decrease in side length could enhance the intensity of vortices in micro-pits.Conclusions The extracellular fluid velocity and wall shear force can be changed by controlling parameters of micro-texture,thus promote the adhesion of cells.

关 键 词：仿生六边形棱柱 吻合钉 平板流动腔 细胞外液流速 壁面剪切力 

分 类 号：R318.01[医药卫生—生物医学工程]