单胎与多胎早产儿视网膜病变发病率及危险因素的比较  

Comparison of incidence and risk factors of retinopathy of prematurity in single and multiple births

作　　者：仲剑锋 李靖宇 刘红[1] 李莹莹 Zhong Jian-feng;Li Jing-yu;Liu Hong(Maternal and Child Health Hospital Affiliated to Nantong University,Nantong 226008,China)

机构地区：[1]南通大学附属妇幼保健院眼科,226008

出　　处：《中国斜视与小儿眼科杂志》2023年第3期21-23,共3页Chinese Journal of Strabismus & Pediatric Ophthalmology

摘　　要：目的比较分析单胎与多胎早产儿视网膜病变发病率及相关危险因素。方法收集2021年1月至2022年6月在南通大学附属妇幼保健院新生儿医学中心住院的早产儿151例,根据出生胎儿数分为单胎组(111例)及多胎组(双胎及以上,40例),应用RetCamⅢ行ROP探查,比较单胎与多胎在不同出生胎龄中ROP和严重病变的发病率及相关危险因素。结果151例早产儿中,单胎组在出生胎龄<28周、28~<32周、32~<34周中ROP及严重病变发病率分别为90.00%、51.95%、7.14%及15.00%、3.90%、0.00%;多胎组75.00%、75.00%、33.33%及0.00%、8.33%、16.67%;两组间比较,出生胎龄在28~<32周的多胎发生ROP的机率明显高于单胎,有统计学差异(P=0.046)。单胎与多胎在不同出生胎龄中发生严重病变的机率均无统计学差异(P>0.05)。在出生胎龄28~<32周的早产儿中,单胎组发生ROP的平均出生胎龄(29.48±1.04)周及平均出生体质量(1277.50±245.78)克与多胎组(28.86±0.92)周及(1170.56±135.45)克比较均有统计学差异(P<0.05)。结论南通地区在出生胎龄28~<32周的早产儿中,ROP的发病率与胎别有关,多胎明显高于单胎,该年龄段多胎的出生胎龄及出生体质量均低于单胎,是多胎更易发生ROP的高危因素。Objective To compare the incidence and risk factors of retinopathy of prematurity(ROP)between singletons and multiplets.Methods A total of 151 premature infants hospitalized in Neonatal Medical Center of Maternal and Child Health Hospital Affiliated to Nantong University from January 2021 to June 2022 were collected and divided into single group(111 cases)and multiple group(40 cases)according to the number of fetuses born.ROP was performed by using wide-field fundus imaging device(RetCamⅢ).To compare the incidence of ROP and severe disease in single and multiple births at different gestational ages and birth weights.Results Among the 151 preterm infants,in the single group,the incidence of ROP and severe disease in GA<28 weeks,28~<32 weeks,32~<34 weeks were 90.00%,51.95%,7.14%and 15.00%,3.90%,0.00%,respectively.The multifetal group was 75.00%,75.00%,33.33%and0.00%,8.33%,16.67%;The incidence of ROP in multifetal group with GA at 28~<32 weeks was significantly higher than that in single group(P=0.046).There was no significant difference in the incidence of severe disease between single and multiple pregnancies in different GA(P>0.05).In preterm infants from GA 28~<32 weeks,the mean GA(29.48±1.04)weeks and BW(1277.50±245.78)g for ROP in the single group were significantly different from those in the multiple group(28.86±0.92)weeks and(1170.56±135.45)g(P<0.05).Conclusions In Nantong area,the incidence of ROP of preterm infants with GA of 28~<32 weeks is related to the fetus,and the incidence of ROP of multiple births is significantly higher than that of single births.The GA and BW of multiple births in this age group are lower than that of single births,which is the risk factor for the occurrence of ROP in multiple births.

关 键 词：早产儿视网膜病变 单胎 多胎 发病率 

分 类 号：R722.6[医药卫生—儿科]