嵌合状态分析在异基因造血干细胞移植中的应用现状  

Research status on chimerism analysis in allogenetic hematopoietic stem cell transplantation

作　　者：王佳雯 朱晗[1] 缪扣荣[1] Wang Jiawen;Zhu Han;Miao Kourong(Department of Hematology,First Affiliated Hospital of Nanjing Medical University,Jiangsu Province Hospital,Nanjing 210029,Jiangsu Province,China)

机构地区：[1]南京医科大学第一附属医院,江苏省人民医院血液科,南京210029

出　　处：《国际输血及血液学杂志》2023年第4期307-313,共7页International Journal of Blood Transfusion and Hematology

基　　金：国家自然科学基金(81470329)。

摘　　要：异基因造血干细胞移植(allo-HSCT)是目前多种血液系统恶性疾病的唯一治愈方法,但其移植成功率受较多因素影响,如移植物抗宿主病(GVHD)、疾病复发及严重感染等。而移植物植入状态对GVHD和复发的早期预测和抢先干预尤为重要。嵌合状态分析作为检测allo-HSCT后移植物植入状态的常用方法,可及时、有效监测疾病状态,并且为后续治疗策略提供指导。笔者拟就嵌合状态分析方法及其作用、细胞谱系特异性嵌合状态分析,以及嵌合状态分析在非恶性疾病(NMD)中的应用等方面的研究现状进行阐述,旨在为提高allo-HSCT成功率提供参考。Allogeneic hematopoietic stem cell transplantation(allo-HSCT)is the only cure method for many hematological malignant diseases in current,but there are also many factors affecting the success of transplantation,such as graft-versus-host disease(GVHD),disease recurrence and severe infection.Graft implantation status is particularly important for early prediction and preemptive intervention of GVHD and recurrence.As a common method to detect the implantation status of grafts after allo-HSCT,chimeric analysis can conduct timely and effectively monitoring of disease status,and provide guidance for subsequent treatment strategies.This article intends to elaborate on current research status of chimerism analysis methods and their roles,cell lineage-specific chimerism analysis,and the application of chimerism analysis in non-malignant diseases(NMD),in order to improve success of allo-HSCT.

关 键 词：造血干细胞移植 嵌合状态 移植物抗宿主病 细胞谱系 预测 预后 

分 类 号：R457.7[医药卫生—治疗学]