一种妥曲珠利的杂质合成与表征  

Synthesis and characterization of a kind of impourities in toltrazuril

作　　者：杨杰 王中平 李慧娟 尹逊慧 YANG Jie;WANG Zhong-ping;LI Hui-juan;YIN Xun-hui(Jiangsu Lingyun Pharmaceutical Co.,Ltd.,Changzhou 213200,China;Shandong Province Liangshan County Animal Husbandry and Veterinary Development Center,Liangshan 272600,China)

机构地区：[1]江苏凌云药业股份有限公司,江苏常州213200 [2]山东省梁山县畜牧兽医事业发展中心,山东梁山272600

出　　处：《精细与专用化学品》2023年第10期47-49,共3页Fine and Specialty Chemicals

摘　　要：通过亲核加成、缩合、环合和酸化反应得到了一种在抗球虫药物妥曲珠利合成过程中存在的杂质1-(4-氯苯基)-3-甲基-1,3,5-三嗪-2,4,6-三酮,并对合成的杂质进行了表征。An impurity 1-(4-chlorophenyl)-3-methyl-1,3,5-triazine-2,4,6-trione was successfully obtained through nucleophilic addition,condensation,cyclization,and acidification reactions,and the synthesized impurity was characterized.

关 键 词：抗球虫药物 妥曲珠利 杂质 合成 

分 类 号：TQ460.6[化学工程—制药化工]