3D打印钛合金植入物结构对6 MV X线剂量的影响  

Effect of 3D Printed Titanium Alloy Implant Structure on 6 MV X-ray Dose

作　　者：管凯 陈贞霞 史训莹 赵晓岚 陈凯琪 郑凤标 王爱民 GuanKai;Chen Zhenxia;Shi Xunying;Zhao Xiaolan;Chen Kaiqi;Zheng Fengbiao;Wang Aimin(Zhangzhou Third Hospital,Zhangzhou Fujian 363005,China)

机构地区：[1]漳州市第三医院,福建漳州363005

出　　处：《医疗装备》2023年第20期1-5,共5页Medical Equipment

基　　金：漳州市自然科学基金项目(ZZ2021J33)。

摘　　要：目的探讨3D打印钛合金(Ti_(6)Al_(4)V)植入物结构对6 MV X线剂量的影响。方法采用激光选区熔化技术制造3D打印钛合金植入物,并使用激光抛光处理其表面;使用医用电子直线加速器产生的6 MV X射线照射植入物,通过指型电离室辅以静电计测量植入物前后表面的剂量,同时将植入物样及水箱扫描导入放射治疗计划系统(TPS),利用放射治疗计划系统的算法,计算植入物前后表面剂量,分析植入物厚度、网格密度及抛光处理对射线剂量的影响。结果当钛合金植入物位于电离室前表面时,测得的平均剂量随植入物厚度的减小和网格密度的增加而增加,剂量变化(降低)幅度随植入物厚度的减小和网格密度的增加而减小;植入物经激光抛光处理后,植入物后方的剂量变化幅度减小。而当植入物位于电离室后表面时,测得的平均剂量和剂量变化与植入物的网格密度和厚度无明显关系。此外,比较植入物前方和后方的平均剂量发现,植入物前方的剂量值通常高于后方的剂量值。结论钛合金植入物网格密度增加、厚度减小时,对放射治疗剂量的影响变小;若对钛合金植入物表面进行抛光处理,则影响会进一步减小,可为临床治疗提供参考依据,有助于医师制定更精准的治疗方案,优化放射治疗的疗效。Objective The effect of 3D printed titanium alloy(Ti_(6)Al_(4)V)implant structure on 6 MV X-ray dose was explored.Methods Using laser selective melting technology to manufacture 3D printed titanium alloy implants,and using laser polishing to treat their surfaces.Using 6 MV X-ray generated by a medical electronic linear accelerator to irradiate the implant,the dose values on the front and rear surfaces of the implant were measured using a finger-shaped ionization chamber supplemented by an electrometer.At the same time,the implant sample and water tank were scanned and imported into treatment planning system(TPS).The algorithm of TPS was used to calculate the surface dose before and after the implant,and the effects of implant thickness,grid density,and polishing treatment on the radiation dose were analyzed.Results When the titanium alloy implant was located on the front surface of the ionization chamber,the measured average dose increases with a decrease in implant thickness and an increase in grid density,and the magnitude of dose change(decrease)decrease with a decrease in implant thickness and an increase in grid density;After laser polishing of the implant,the magnitude of dose changed behind the implant decreases.When the implant was located on the surface behind the ionization chamber,the measured average dose and dose changes were not significantly related to the grid density and thickness of the implant.In addition,comparing the average dose before and after the implant,it was found that the dose value before the implant was usually higher than the dose value behind it.Conclusion The increase in grid density and decrease in thickness of titanium alloy implants have a smaller impact on radiation therapy dose;If the surface of titanium alloy implants is polished,the impact will be further reduced,which can provide a reference basis for clinical treatment,help physicians formulate more accurate treatment plans,and optimize the efficacy of radiation therapy.

关 键 词：放射治疗 3D打印钛合金 植入物 放射剂量 

分 类 号：R815[医药卫生—放射医学]