多发骨髓瘤患者应用硼替佐米致急性胰腺炎二例  

Bortezomib-induced acute pancreatitis in patients with multiple myeloma:two case reports

作　　者：郑彬[1] 李天弋 王超[1] 肖莹[1] 张弋[1] 蒋怡丽 彭新冬 ZHENG Bin;LI Tian-yi;WANG Chao;XIAO Ying;ZHANG Yi;JIANG Yi-li;PENG Xin-dong(Department of Pharmacy,Tianjin First Central Hospital,Tianjin 300192,China;College of Pharmaceutical Engineering of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Department of Hematology,Tianjin First Central Hospital,Tianjin 300192,China;Department of Imaging,PLA 95829 Army Hospital,Wuhan 420012,China)

机构地区：[1]天津市第一中心医院药学部,天津300192 [2]天津中医药大学中药制药工程学院,天津301617 [3]天津市第一中心医院血液科,天津300192 [4]中国人民解放军95829部队医院影像科,武汉420012

出　　处：《临床药物治疗杂志》2023年第10期90-92,共3页Clinical Medication Journal

基　　金：天津市卫生健康委科技人才培育项目(KJ20030)。

摘　　要：本文报道2例多发骨髓瘤患者应用硼替佐米之后出现腹胀、腹痛等症状,并伴有血清淀粉酶、脂肪酶水平升高,考虑为硼替佐米导致的急性胰腺炎罕见不良反应,经过药学干预和对症治疗后,患者的不良反应好转。We reported two cases of multiple myeloma patients experiencing abdominal distension and pain,accompanied by elevated serum amylase and lipase levels.These were considered acute pancreatitis as rare adverse drug reaction caused by bortezomib.The patients'adverse reactions improved after receiving pharmaceutical intervention and symptomatic treatment.

关 键 词：硼替佐米 急性胰腺炎 多发骨髓瘤 罕见不良反应 

分 类 号：R979.1[医药卫生—药品] R969.3[医药卫生—药学]