基于关联规则的慢性阻塞性肺疾病中医用药配伍规律分析  

An analysis of law of TCM medicine compatibility in treating chronic obstructive pulmonary disease based on association rules

作　　者：崔长姣 张毅[1] 吴建军 郑贵森 何江宁 赵亚敏 魏兴民[1] CUI Changjiao

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]西北环境与营养相关疾病中医药防控研究2011协同创新中心,甘肃兰州730000

出　　处：《中医临床研究》2023年第28期48-53,共6页Clinical Journal Of Chinese Medicine

基　　金：西北营养与环境相关疾病中医药防控协同创新中心2020年度开放基金(ZYXT-20-03)。

摘　　要：目的:运用数据挖掘分析慢性阻塞性肺疾病用药规律。方法:在中国知网检索中医药治疗慢性阻塞性肺疾病的文章,对数据标准化后构建处方数据库,借助R4.0软件进行数据的频次、关联规则、聚类等分析。结果:(1)使用频率>30%中药,稳定期有黄芪、白术、茯苓、党参、陈皮、半夏、甘草,急性加重期有半夏、苦杏仁、黄芩、甘草、紫苏子;(2)稳定期用药四气以温、平性多见,五味以辛、甘味为主,多入肺、肾、脾经;急性加重期用药四气以温、寒性多见,五味以辛、甘味为主,多入肺经;(3)稳定期高频药物药对组合有桔梗-党参、黄芩-熟地黄-五味子、半夏-党参-茯苓-陈皮、半夏-党参-茯苓-甘草-陈皮,急性加重期有莱菔子-紫苏子、黄芩-紫苏子-桑白皮、半夏-桑白皮-紫苏子-苦杏仁;(4)稳定期药物可聚为4类,急性加重期可聚为6类。结论:稳定期用药重在理气健脾、补中益气,急性加重期用药重在清热化痰、活血化瘀,而燥湿化痰类中药贯穿始终。Objective:To analyze law of TCM medicine compatibility in treating chronic obstructive pulmonary disease by data mining.Methods:Articles on the treatment of chronic obstructive pulmonary disease with TCM medicine were retrieved from CNKI,and the prescription database was constructed after data standardization.The frequency,association rules and clustering of theO data were analyzed by R4.0 software.Results:(1)TCM medicine used more than 30%in the stable stage included Huangqi(Radix Astragali),Baizhu(Rhizoma Atractylodis Macrocephalae),Fuling(Poria),Dangshen(Radix Codonopsis),Chenpi(Pericarpium Citri Reticulatae),Banxia(Rhizoma Pinelliae),Gancao(Radix Glycyrrhizae).In the acute exacerbation,there were Banxia,Kuxingren(Semen Armeniacae Amarum),Huangqin(Radix Scutellariae),Gancao,Zisuzi(Fructus Perillae).(2)During the stable period,the TCM medicine with warm and neutral of the four Qi(气)were more chosen.And the five flavors were mainly acrid and sweet,which enter the lung,kidney and spleen channels.In the acute exacerbation stage,the four Qi were mainly warm and cold,and the five flavors were mainly acrid and sweet,which mainly entered the lung channel.(3)In stable phase,high frequency couplet medicines included Jiegeng(Radix Platycodonis)-Dangshen,Huangqin-Shudihuang(Radix Rehmanniae Preparata)-Wuweizi(Fructus Schisandrae Chinensis),Banxia-Dangshen-Fuling-Chenpi,Banxia-Dangshen-Fuling-Gancao-Chenpi.In the acute exacerbation period,there were Laifuzi(Semen Raphani)-Zisuzi,Huangqin-Zisuzi-Sangbaipi(Cortex Mori),Banxia-Sangbaipi-Zisuzi-Kuxingren.(4)In stable period,TCM medicine can be clustered into four categories,and in acute exacerbation period,TCM medicine can be clustered into 6 categories.Conclusion:In the stable stage,the medication should focus on regulating Qi,strengthening spleen,invigorating spleen and replenishing Qi.In the acute exacerbation stage,the medication should focus on clearing heat and removing phlegm,promoting blood circulation and removing blood stasis.TCM medicine of removing dampness to re

关 键 词：慢性阻塞性肺疾病 稳定期 急性加重期 中医药 用药规律 

分 类 号：R256.1[医药卫生—中医内科学]