心力衰竭病人外周血α-HBD、MYO、LDH、NT-proBNP水平与心室重塑、心脏储备功能的相关性  

Correlation between Peripheral Bloodα-HBD,MYO,LDH,NT-proBNP Levels and Ventricular Remodeling,Cardiac Reserve Function in Patients with Heart Failure

作　　者：朱吉燕 ZHU Jiyan(Sichuan Mianyang 404 Hospital,Mianyang 621000,Sichuan,China)

机构地区：[1]四川绵阳四〇四医院,四川绵阳621000

出　　处：《中西医结合心脑血管病杂志》2023年第21期3997-4000,共4页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的:分析外周血α-羟丁酸脱氢酶(α-HBD)、肌红蛋白(MYO)、乳酸脱氢酶(LDH)、N末端B型脑钠肽前体(NT-proBNP)水平与心力衰竭病人心室重塑、心脏储备功能的相关性。方法:选取2019年8月—2022年8月四川绵阳四〇四医院收治的213例心力衰竭病人为观察组,另选取同期体检的150名健康者作为对照组,采用酶联免疫吸附试验(ELISA)检测外周血α-HBD、MYO、LDH及NT-proBNP水平,采用超声心动图测定心室重塑[舒张末期室间隔厚度(IVST)、左心室舒张末期后壁厚度(LVPWT)、左心室重量(LVM)、左心室重量指数(LVMI)]、心脏储备功能[左心室射血分数(LVEF)、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、6 min步行距离(6MWD)],采用Pearson相关性分析法分析外周血α-HBD、MYO、LDH及NT-proBNP水平与心室重塑、心脏储备功能指标的相关性。结果:观察组外周血α-HBD、MYO、LDH及NT-proBNP水平高于对照组(P<0.001)。观察组IVST、LVPWT、LVM、LVMI高于对照组(P<0.001)。观察组LVEF、6MWD小于对照组(P<0.001),LVEDD、LVESD大于对照组(P<0.001)。Pearson相关分析显示,外周血α-HBD、MYO、LDH及NT-proBNP水平与IVST、LVPWT、LVM、LVMI、LVEDD、LVESD呈正相关(P<0.05),与LVEF、6MWD呈负相关(P<0.05)。结论:心力衰竭病人外周血α-HBD、MYO、LDH及NT-proBNP水平越高,心脏储备功能越低,且与心室重构呈正相关,可评价心力衰竭心功能。Objective:To analyze the correlation between the levels ofα-hydroxybutyrate dehydrogenase(α-HBD),myoglobin(MYO),lactate dehydrogenase(LDH),N-terminal B-type brain natriuretic peptide precursor(NT-proBNP)and ventricular remodeling and cardiac reserve function in patients with heart failure(HF).Methods:A total of 213 patients with HF admitted to the hospital and 150 healthy controls were enrolled as observation group and control group between August 2019 and August 2022,respectively.The levels ofα-HBD,MYO,LDH,and NT-proBNP in peripheral blood were detected by enzyme-linked immunosorbent assay(ELISA).The ventricular remodeling indexes[end-diastolic interventricular septum thickness(IVST),left ventricular posterior wall thickness(LVPWT),left ventricular mass(LVM),LVM index(LVMI)],cardiac reserve function indexes[left ventricular ejection fraction(LVEF),left ventricular end-diastolic dimension(LVEDD),left ventricular end-systolic diameter(LVESD),and 6 minute walking distance(6MWD)]were detected.The correlation between peripheral bloodα-HBD,MYO,LDH,NT-proBNP and ventricular remodeling and cardiac reserve function was analyzed by Pearson correlation coefficient.Results:The levels of peripheral bloodα-HBD,MYO,LDH,and NT-proBNP in observation group were higher than those in control group(P<0.001),IVST,LVPWT,LVM,and LVMI were higher than those in control group(P<0.001).LVEF and 6MWD in observation group were lower than those in control group,while LVEDD and LVESD were higher than those in control group(P<0.001).Pearson correlation analysis showed that the levels ofα-HBD,MYO,LDH,and NT-proBNP were positively correlated with IVST,LVPWT,LVM,LVMI,LVEDD,and LVESD,while negatively correlated with LVEF and 6MWD(P<0.05).Conclusion:The higher the levels of peripheral bloodα-HBD,MYO,LDH,and NT-proBNP,the lower the cardiac reserve function in HF patients,and they are positively correlated with ventricular remodeling,which can be applied as important evaluation indexes for cardiac function.

关 键 词：心力衰竭 Α-羟丁酸脱氢酶 肌红蛋白 乳酸脱氢酶 N末端B型脑钠肽前体 心室重塑 心脏储备功能 相关性 

分 类 号：R541.6[医药卫生—心血管疾病]