聚乙二醇改良方案对肠道准备耐受性及清洁度的影响研究  

Study on the influence of polyethylene glycol modified scheme on the tolerance and cleanliness of intestinal preparation.

作　　者：张莹[1] 解莹[1] 田丰[1] 刘礼维 周林妍[1] ZHANG Ying;XIE Ying;TIAN Feng;LIU Li-wei;ZHOU Lin-yan(Department of Gastroenterology,Shengjing Hospital of China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院消化科,辽宁沈阳110022

出　　处：《中国实用内科杂志》2023年第10期853-857,共5页Chinese Journal of Practical Internal Medicine

基　　金：辽宁省博士科研启动基金计划项目(2022-BS-127)。

摘　　要：目的探讨聚乙二醇改良方案对患者肠道准备的效果、耐受性、不良反应等影响,以寻找更优的肠道清洁方法。方法收集2021年12月1日至2022年9月,在中国医科大学附属盛京医院行无痛肠镜检查患者219例。随机分为4组:聚乙二醇2 L组(54例)、聚乙二醇4 L组(55例)、无糖可乐+聚乙二醇2 L组(53例)、利那洛肽+聚乙二醇2 L组(57例),进行肠道清洁度、肠道准备耐受性及准备时间等方面的评估。结果2 L组的清洁度总分明显低于其他3组(P<0.05)。4 L组在清洁度总分和右半结肠评分中明显高于可乐组(P<0.05)。可乐组的口感评分和重复用药评分均明显高于其他3组(P<0.05)。可乐组的恶心发生率(18.9%)明显低于其他3组;可乐组的呕吐发生率(1.9%)显著低于利那洛肽组(14.0%);腹胀发生率中,可乐组(3.8%)明显低于2 L组(22.2%)和4 L组(27.3%),利那洛肽组(10.5%)明显低于4 L组(P<0.05)。2 h内可乐组全部喝完泻药的患者比例(92.4%)高于2 L组(83.3%)和4 L组(80.0%),但差异无统计学意义。结论无糖可乐冲调聚乙二醇可以改善肠道清洁度,提升适口性,减少不良反应的发生。利那洛肽联合聚乙二醇可以明显提升肠道清洁度,同时减轻腹胀的副反应。Objective To explore the effects,tolerance,and adverse reactions of polyethylene glycol modified schemes on patient intestinal preparation,in order to find better intestinal cleaning methods.Methods Collect 219 patients who underwent painless colonoscopy at Shengjing Hospital affiliated to China Medical University from December 1,2021 to September 2022.Randomly divided into four groups:polyethylene glycol 2L group(54 cases),polyethylene glycol 4L group(55 cases),sugar free Ccola+polyethylene glycol 2L group(53 cases),and linalopide+polyethylene glycol 2L group(57 cases),for evaluation of intestinal cleanliness,intestinal preparation tolerance,and preparation time.Results The total cleanliness score of the 2L group was significantly lower than that of the other 3 groups(P<0.05).The total cleanliness score and right colon score of the 4L group were significantly higher than those of the Coca Cola group(P<0.05).The taste score and repeated medication score of the Cola group were significantly higher than those of the other three groups(P<0.05).The incidence of nausea in the Cola group(18.9%)was significantly lower than the other three groups;The incidence of vomiting in the cola group(1.9%)was significantly lower than that in the linalopide group(14.0%);In the incidence of abdominal distension,the Cola group(3.8%)was significantly lower than the 2 L group(22.2%)and the 4 L group(27.3%),while the linalopide group(10.5%)was significantly lower than the 4 L group(P<0.05).The proportion of patients in the Cola group who drank all the laxatives within 2 hours(92.4%)was significantly higher than that in the 2 L group(83.3%)and the 4 L group(80.0%)but the difference was not statistically significant.Conclution Sugar free Cola mixed with polyethylene glycol can improve intestinal cleanliness,enhance palatability,and reduce the occurrence of adverse reactions.Linalotide combined with polyethylene glycol can significantly improve intestinal cleanliness while reducing the side effects of abdominal distension.

关 键 词：肠道准备 肠道清洁度 聚乙二醇 利那洛肽 

分 类 号：R562[医药卫生—呼吸系统]