MHR与阻塞性睡眠呼吸暂停低通气综合征的相关性研究  

Study on correlation of MHR and obstructive sleep apnea-hypopnea syndrome

作　　者：章婷[1] 刘国亮 张志勇[2] 喻杰[1] ZHANG Ting;LIU Guo-liang;ZHANG Zhi-yong(Second Department of Respiratory Disease,Jiangxi Provincial People's Hospital(The First Affiliated Hospital of Nanchang Medical College),Nanchang 330006,China)

机构地区：[1]江西省人民医院(南昌医学院第一附属医院)二部呼吸与危重症医学科,330006 [2]江西省人民医院(南昌医学院第一附属医院)检验科,330006 [3]江西省进贤县人民医院呼吸与危重症医学科,331700

出　　处：《中国实用医药》2023年第20期1-5,共5页China Practical Medicine

基　　金：江西省中医药管理局科技计划(项目编号:2020A0138);江西省卫生健康委科技计划(项目编号:202130038)。

摘　　要：目的探究单核细胞计数和高密度脂蛋白胆固醇的比值(MHR)与阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者的相关性。方法选取94例OSAHS患者,根据睡眠呼吸暂停低通气指数(AHI)分为轻度组(5次/h≤AHI<15次/h,23例)、中度组(15次/h≤AHI<30次/h,14例)和重度组(AHI≥30次/h,57例);另选取经多导睡眠监测(PSG)AHI<5次/h排除OSAHS的健康受试者12例作为对照组。检测并比较对照组与OSAHS组及其亚组的基本情况和睡眠监测指标,分析单核细胞计数(MC)、高密度脂蛋白胆固醇(HDL-C)、MHR与睡眠监测各指标的相关性。结果对照组MC、HDL-C、MHR、AHI、最低血氧饱和度(SpO_(2))、平均SpO_(2)、氧减指数、最长呼吸暂停时间分别为(0.38±0.07)×10^(9)/L、(1.34±0.30)mmol/L、(0.30±0.06)、(2.40±1.54)次/h、(86.93±2.72)%、(97.26±0.28)%、(2.88±2.29)次/h、(49.25±10.36)s,OSAHS组MC、HDL-C、MHR、AHI、最低SpO_(2)、平均SpO_(2)、氧减指数、最长呼吸暂停时间分别为(0.50±0.15)×10^(9)/L、(1.03±0.17)mmol/L、(0.51±0.16)、(36.73±21.30)次/h、(73.19±15.23)%、(95.32±3.06)%、(26.66±22.13)次/h、(69.08±18.75)s,轻度组MC、HDL-C、MHR、AHI、最低SpO_(2)、平均SpO_(2)、氧减指数、最长呼吸暂停时间分别为(0.42±0.04)×10^(9)/L、(1.13±0.15)mmol/L、(0.38±0.12)、(9.75±2.72)次/h、(84.21±2.66)%、(96.84±0.50)%、(5.37±3.39)次/h、(61.09±8.71)s,中度组MC、HDL-C、MHR、AHI、最低SpO_(2)、平均SpO_(2)、氧减指数、最长呼吸暂停时间分别为(0.50±0.05)×10^(9)/L、(1.03±0.07)mmol/L、(0.55±0.01)、(21.50±4.82)次/h、(78.31±12.75)%、(96.39±0.61)%、(11.27±5.25)次/h、(67.36±8.37)s,重度组MC、HDL-C、MHR、AHI、最低SpO_(2)、平均SpO_(2)、氧减指数、最长呼吸暂停时间分别为(0.53±0.04)×10^(9)/L、(0.99±0.06)mmol/L、(0.56±0.01)、(51.36±13.16)次/h、(67.49±14.87)%、(94.44±3.49)%、(39.03±20.05)次/h、(72.72±6.69)s。OSAHS组患者的MC、MHR、AHI、氧减指数均高于�Objective To investigate the correlation of monocyte-to-high-density lipoprotein cholesterol ratio(MHR)and obstructive sleep apnea-hypopnea syndrome(OSAHS).Methods According to apnea hypopnea index(AHI),a total of 94 OSAHS patients were selected and divided into mild group(5 times/h≤AHI<15 times/h,23 cases),moderate group(15 times/h≤AHI<30 times/h,14 cases)and severe group(AHI≥30 times/h,57 cases).Another 12 healthy subjects without OSAHS confirmed by polysomnography(PSG)were selected as the control group.The basic information and sleep monitoring indexes of the control group and OSAHS group and its subgroups were detected and compared,and the correlation of mononuclear cell count(MC),high-density lipoprotein cholesterol(HDL-C),MHR with sleep monitoring indexes was analyzed.Results In control group,MC,HDL-C,MHR,AHI,lowest blood oxygen saturation(SpO_(2)),average SpO_(2),oxygen desaturation index,and longest apnea time were(0.38±0.07)×10^(9)/L,(1.34±0.30)mmol/L,(0.30±0.06),(2.40±1.54)times/h,(86.93±2.72)%,(97.26±0.28)%,(2.88±2.29)times/h,and(49.25±10.36)s;in OSAHS group,MC,HDL-C,MHR,AHI,minimum blood oxygen saturation(SpO_(2)),average SpO_(2),oxygen desaturation index,and longest apnea time were(0.50±0.15)×10^(9)/L,(1.03±0.17)mmol/L,(0.51±0.16),(36.73±21.30)times/h,(73.19±15.23)%,(95.32±3.06)%,(26.66±22.13)times/h,and(69.08±18.75)s;in mild group,MC,HDL-C,MHR,AHI,minimum blood oxygen saturation(SpO_(2)),average SpO_(2),oxygen desaturation index,and longest apnea time were(0.42±0.04)×10^(9)/L,(1.13±0.15)mmol/L,(0.38±0.12),(9.75±2.72)times/h,(84.21±2.66)%,(96.84±0.50)%,(5.37±3.39)times/h,and(61.09±8.71)s;in the moderate group,MC,HDL-C,MHR,AHI,minimum blood oxygen saturation(SpO_(2)),average SpO_(2),oxygen desaturation index,and longest apnea time were(0.50±0.05)×10^(9)/L,(1.03±0.07)mmol/L,(0.55±0.01),(21.50±4.82)times/h,(78.31±12.75)%,(96.39±0.61)%,(11.27±5.25)times/h,and(67.36±8.37)s;in severe group,MC,HDL-C,MHR,AHI,minimum blood oxygen saturation(SpO_(2)),average SpO_(2),ox

关 键 词：单核细胞计数和高密度脂蛋白胆固醇的比值 阻塞性睡眠呼吸暂停低通气综合征 相关性 

分 类 号：R766[医药卫生—耳鼻咽喉科]