血清HBV-DNA联合免疫球蛋白检测对慢性乙型肝炎诊断的临床价值  

Clinical Value of Serum HBV-DNA Combined with Immunoglobulin Detection in the Diagnosis of Chronic Hepatitis B

作　　者：许婷 李媛媛 XU Ting;LI Yuan-yuan(Department of Laboratory,Yichun City Hospital of Traditional Chinese Medicine,Yichun 336000,Jiangxi,China)

机构地区：[1]宜春市中医院检验科,江西宜春336000

出　　处：《医学信息》2023年第22期156-159,共4页Journal of Medical Information

摘　　要：目的探究血清乙肝病毒-脱氧核糖核酸(HBV-DNA)联合免疫球蛋白检测对慢性乙型肝炎的诊断价值。方法以2022年3月-2023年3月宜春市中医院收治的70例慢性乙肝患者为研究对象设为乙肝组,另取70例同期体检健康者设为健康组,对两组血清HBV-DNA与免疫球蛋白指标(IgG、IgA、IgM)进行检测,比较其检测结果,统计血清HBV-DNA与免疫球蛋白检测对乙肝的阳性检出率,分析不同病情程度患者的血清HBV-DNA与免疫球蛋白水平。结果乙肝组血清HBV-DNA与免疫球蛋白(IgG、IgA、IgM)水平均高于健康组(P<0.05);血清HBV-DNA与免疫球蛋白联合检测的乙肝阳性检出率高于其单独检测(P<0.05);不同病情分级患者的血清HBV-DNA与免疫球蛋白水平比较,差异有统计学意义(P<0.05),其血清HBV-DNA与免疫球蛋白水平由高至低依次为重度>中度>轻度。结论血清HBV-DNA与免疫球蛋白检测在慢性乙肝诊断中具有确切应用价值,二者联合检测可提高乙肝阳性检出率,对其病情严重程度具有一定评估作用。Objective To explore the diagnostic value of serum hepatitis B virus-deoxyribonucleic acid(HBV-DNA)combined with immunoglobulin detection in chronic hepatitis B.Methods A total of 70 patients with chronic hepatitis B admitted to Yichun Hospital of Traditional Chinese Medicine from March 2022 to March 2023 were selected as the hepatitis B group,and 70 healthy people who underwent physical examination during the same period were selected as the healthy group.The serum HBV-DNA and immunoglobulin indexes(IgG,IgA,IgM)of the two groups were detected,and the detection results were compared.The positive detection rate of serum HBV-DNA and immunoglobulin detection for hepatitis B was counted,and the serum HBV-DNA and immunoglobulin levels of patients with different degrees of illness were analyzed.Results The levels of serum HBV-DNA and immunoglobulin(IgG,IgA,IgM)in hepatitis B group were higher than those in healthy group(P<0.05).The positive rate of hepatitis B detected by combined detection of serum HBV-DNA and immunoglobulin was higher than that detected alone(P<0.05).There were statistically significant differences in serum HBV-DNA and immunoglobulin levels among patients with different disease grades(P<0.05).The levels of serum HBV-DNA and immunoglobulin from high to low were severe>moderate>mild.Conclusion The detection of serum HBV-DNA and immunoglobulin has definite application value in the diagnosis of chronic hepatitis B.The combined detection of the two can improve the positive detection rate of hepatitis B and has a certain evaluation effect on the severity of the disease.

关 键 词：慢性乙型肝炎 HBV-DNA 免疫球蛋白 联合检测 阳性检出率 病情分级 

分 类 号：R512.62[医药卫生—内科学] R446.6[医药卫生—临床医学]