高血压前期患者颈动脉血管弹性超声参数与左室舒张功能的关系研究  

Study on the Relationship between Carotid Artery Elastic Ultrasound Parameters and Left Ventricular Diastolic Function in Patients with Prehypertension

作　　者：郑英娟[1] 李朝喜[1] 牛亚军[1] 高辰玮[1] 张婷 ZHENG Ying-juan;LIChao-xi;NIU Ya-jun;GAO Chen-wei;ZHANG Ting(Department of Ultrasound Medicine,The First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei,075000,China)

机构地区：[1]河北北方学院附属第一医院超声医学科,河北张家口075000

出　　处：《现代生物医学进展》2023年第18期3543-3547,共5页Progress in Modern Biomedicine

基　　金：河北省2020年度医学科学研究课题计划项目(20200200);张家口市科学技术研究与发展计划项目(1911021D-4)。

摘　　要：目的:研究高血压前期患者颈动脉血管弹性超声参数与左室舒张功能的关系。方法:选取2019年12月-2020年12月因血压异常于河北北方学院附属第一医院接受诊断与治疗的161例患者,根据血压水平分为高血压前期组(82例)与高血压组(79例);另选取同期于我院体检的80例健康志愿者作为对照组。收集三组临床资料,检测生化指标与血压;通过超声诊断仪中超声射频信号血管内中膜定量分析(QIMT)与动脉僵硬度定量分析(QAS)软件测量颈动脉血管弹性超声参数[颈动脉内中膜厚度(IMT)、顺应性系数(CC)、扩张性系数(DC)、血管弹性指数(α、β)、脉搏波传导速度(PWV)];超声心动图检查左室功能指标[左室射血分数(LVEF)、左室质量指数(LVMI)、舒张早期血流速度峰值(E)/舒张晚期血流速度峰值(A)、等容舒张时间(IVRT)、舒张期减速时间(DT)];采用Pearson相关性法分析颈动脉血管弹性超声参数与心室指标的相关性。结果:三组收缩压与舒张压水平存在统计学意义(P<0.05)。高血压前期组与高血压组IMT、α、β、PWV高于对照组,DC、CC低于对照组(P<0.05),且高血压前期组IMT、α、β、PWV低于高血压组,DC、CC高于高血压组(P<0.05)。高血压前期与高血压组E/A低于对照组,IVRT、DT高于对照组(P<0.05),且高血压前期组E/A高于高血压组,IVRT、DT低于高血压组(P<0.05)。经Peason相关性分析显示,IMT、α、β、PWV与E/A呈负相关,与IVRT、DT呈正相关(P<0.05);DC、CC与E/A呈正相关,与IVRT、DT呈负相关(P<0.05)。结论:高血压前期患者颈动脉血管弹性功能下降,且伴有左室舒张功能受损,颈动脉血管弹性超声参数与左室舒张功能密切相关。Objective:To study the relationship between carotid artery elastic ultrasound parameters and left ventricular diastolic function in patients with prehypertension.Methods:161 patients who were diagnosed and treated in the First Affiliated Hospital of Hebei North University from December 2019 to December 2020 due to abnormal blood pressure were selected,and they were divided into prehypertension group(82 cases)and hypertension group(79 cases)according to blood pressure level.Another 80 healthy volunteers who underwent physical examination in our hospital during the same period were selected as the control group.Clinical data of three groups were collected,and biochemical indexes and blood pressure were detected.The carotid artery elastic ultrasound parameters[carotid intima-media thickness(IMT),compliance coefficient(CC),dilation coefficient(DC),vascular elasticity index(α,β)and pulse wave conduction velocity(PWV)]were measured by the software of quality intima-media thickness(QIMT)and quantitative arterial stiffness(QAS)of ultrasonic radiofrequency signal in ultrasonic diagnostic instrument.Left ventricular function indexes[left ventricular ejection fraction(LVEF),left ventricular mass index(LVMI),peak early diastolic blood flow velocity(E)/peak late diastolic blood flow velocity(A),isovolumic relaxation time(IVRT),and diastolic deceleration time(DT)]were examined by echocardiography.Pearson correlation method was used to analyze the correlation between carotid artery elastic ultrasound parameters and ventricular indexes.Results:The systolic blood pressure and diastolic blood pressure levels were statistically significant in the three groups(P<0.05).The IMT,α,βand PWV in the prehypertensive group and the hypertension group were higher than those in the control group,and the DC and CC were lower than those in the control group(P<0.05).The IMT,α,βand PWV in the prehypertensive group were lower than those in the hypertension group,and the DC and CC were higher than those in the hypertension group(P<0.05).E/A in

关 键 词：高血压前期 颈动脉 血管弹性 超声参数 左室舒张功能 相关性 

分 类 号：R544.1[医药卫生—心血管疾病] R543.5[医药卫生—内科学]