普济痔疮栓联合化浊解毒方保留灌肠治疗肛窦炎的疗效及对疼痛介质、免疫功能和复发率的影响  

Effect of Puji Zhichuang Suppository Combined with Huazhuo Jiedu Formula Retention Enema in the Treatment of Anal Sinusitis and its Influence on Pain Mediators,Immune Function and Recurrence Rate

作　　者：陈善虎 麻倩[1] 吴春晓[1] 彭红[2] 宋易华[1] CHEN Shan-hu;MA Qian;WU Chun-xiao;PENG Hong;SONG Yi-hua(Department of Anorectal Surgery,Hebei Provincial Hospital of Traditional Chinese Medicine,Shijiazhuang,Hebei,050000,China;Department of Gastrointestinal Tumor Surgery,Hebei Provincial Hospital of Traditional Chinese Medicine,Shijiazhuang,Hebei,050000,China)

机构地区：[1]河北省中医院肛肠外科,河北石家庄050000 [2]河北省中医院消化道肿瘤外科,河北石家庄050000

出　　处：《现代生物医学进展》2023年第18期3577-3581,共5页Progress in Modern Biomedicine

基　　金：河北省中医药管理局中医药类科研计划项目(2020111)。

摘　　要：目的:探讨普济痔疮栓联合化浊解毒方保留灌肠治疗肛窦炎的疗效及对疼痛介质、免疫功能和复发率的影响。方法:选取我院2020年1月至2021年7月确诊的100例肛窦炎患者。按随机数字表法分为对照组(普济痔疮栓治疗,50例)和实验组(普济痔疮栓联合化浊解毒方保留灌肠治疗,50例)。对比两组疗效、中医证候积分、疼痛介质、免疫功能和复发率的变化情况。结果:实验组的临床总有效率高于对照组(P<0.05)。实验组治疗2个疗程后肛门坠胀及隐痛、排便不尽感、肛门潮湿评分低于对照组(P<0.05)。实验组治疗2个疗程后CD8^(+)低于对照组;CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)高于对照组(P<0.05)。实验组治疗2个疗程后前列腺素E2(PGE2)、P物质(SP)、多巴胺(DA)、五羟色胺(5-HT)低于对照组(P<0.05)。实验组治疗后4个月、6个月的复发率低于对照组(P<0.05)。结论:普济痔疮栓联合化浊解毒方保留灌肠治疗肛窦炎,可促进临床症状改善,降低复发率,可能与降低疼痛介质水平和调节机体免疫功能有关。Objective:To investigate the effect of Puji Zhichuang suppository combined with Huazhuo Jiedu formula retention enema in the treatment of anal sinusitis and its influence on pain mediators,immune function and recurrence rate.Methods:100 patients with anal sinusitis who were diagnosed in our hospital from January 2020 to July 2021 were selected.According to the random number table method,they were divided into control group(treated with Puji Zhichuang suppository,50 cases)and experimental group(Puji Zhichuang suppository combined with Huazhuo Jiedu formula retention enema treatment,50 cases).Changes in efficacy,traditional Chinese medical syndrome score,pain mediators,immune function and recurrence rate in the two groups were compared.Results:The total effective rate in the experimental group was higher than that in the control group(P<0.05).After 2 courses of treatment,the scores of fallen anus and dull pain,anal incomplete defecation,and anal dampness in the experimental group were lower than those of the control group(P<0.05).CD8^(+)in the experimental group after 2 courses of treatment was lower than that in the control group.CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in the experimental group were higher than those of the control group(P<0.05).After 2 courses of treatment,prostaglandin E2(PGE2),Substance P(SP),dopamine(DA)and 5-hydroxytryptamine(5-HT)in the experimental group were lower than those of the control group(P<0.05).The recurrence rate in the experimental group at 4 months and 6 months after treatment were lower than those in the control group(P<0.05).Conclusion:Puji Zhichuang suppository combined with Huazhuo Jiedu formula retention enema in the treatment of anal sinusitis can promote the improvement of clinical symptoms,and reduce the recurrence rate,which may be related to reducing the pain mediators level and regulating the immune function of the body.

关 键 词：普济痔疮栓 化浊解毒方 保留灌肠 肛窦炎 疗效 疼痛介质 免疫功能 复发率 

分 类 号：R657.18[医药卫生—外科学]