腹膜透析管出口感染患者使用替考拉宁致药物热1例并文献阅读  

Drug Fever Caused by Teicoplanin in Patients with Infection of Peritoneal Dialysis Catheter Exit-Site:A CaseReportand LiteratureReview

作　　者：吴慧仪[1] 郑萍[1] 李亦蕾[1] 吴文锋 WU Huiyi;ZHENG Ping;LI Yilei;WU Wenfeng(Clinical Pharmacy Center,Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong 510515,China)

机构地区：[1]南方医科大学南方医院临床药学中心,广东广州510515

出　　处：《今日药学》2023年第9期712-716,共5页Pharmacy Today

基　　金：广东省医院药学研究基金(2022A03);广东省医院协会药学科研专项基金(2022YXKY14);南方医科大学南方医院院长基金(2020C034)。

摘　　要：本文报告1例腹膜透析管出口感染患者使用替考拉宁抗感染治疗5 d后体温恢复正常,体征及各项检验、检查均提示病情好转。在使用替考拉宁10 d后再次出现反复高热。临床药师查阅大量的相关文献资料,结合药物热发生的特点,对患者用药进行综合性分析,考虑为替考拉宁所致药物热,协助医师调整抗感染治疗方案,建议停用替考拉宁,患者病情好转,取得较好的效果。本文有助于提高临床对替考拉宁所致药物热的警觉性及体现临床药师积极参与临床治疗、保障患者用药安全的重要作用。In this paper,a patient with infection of peritoneal dialysis catheter exit-site was treated with teicoplanin for 5 days,and the body temperature returned to normal.Recurrent fever reappeared 10 days after the use of teicoplanin.Clinical pharmacist consulted a large number of relevant literature,combined with the characteristics of drug fever,made a comprehensive analysis.Finally,teicoplanin was highly suspected to be the cause of the fever,and clinical pharmacist proposed to discontinue it,which achieved good results.The present case suggests the importance for clinicians to increase the awareness of teicoplanin-induced fever and clinical pharmacist plays a positive role in optimizing pharmacotherapy and improving the safety of patient.

关 键 词：替考拉宁 药物热 不良反应 

分 类 号：R969[医药卫生—药理学]