Association between maternal gestational diabetes and allergic diseases in offspring:a birth cohort study  

作　　者：Yu-Jing Chen Li-Zi Lin Zhao-Yan Liu Xin Wang Shamshad Karatela Yu-Xuan Wang Shan-Shan Peng Bi-Bo Jiang Xiao-Xu Li Nan Liu Jin Jing Li Cai 

机构地区：[1]Department of Maternal and Child Health,School of Public Health,Sun Yat-Sen University,No.74 Zhongshan Road 2,Yuexiu District,Guangzhou 510080,Guangdong Province,People’s Republic of China [2]Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment,Department of Occupational and Environmental Health,School of Public Health,Sun Yat-Sen University,Guangzhou,People’s Republic of China [3]Department of Nutrition,School of Public Health,Sun Yat-Sen University,Guangzhou,People’s Republic of China [4]Guangdong Provincial Key Laboratory of Food,Nutrition and Health,School of Public Health,Sun Yat-Sen University,Guangzhou,People’s Republic of China [5]Key Laboratory of Brain,Cognition and Education Sciences,Ministry of Education,Guangzhou,China [6]Faculty of Health and Behavioural Sciences,Pharmacy Australia Centre of Excellence,University of Queensland,Woolloongabba,QLD,Australia [7]Global Health Research Center,Duke Kunshan University,Kunshan,People’s Republic of China [8]Department of Medical Statistics,School of Public Health,Sun Yat-Sen University,Guangzhou,People’s Republic of China [9]Institute for Brain Research and Rehabilitation,South China Normal University,Guangzhou,People’s Republic of China [10]Institute of Tropical Health and Medicine(AITHM),James Cook University,Townsville,QLD,Australia

出　　处：《World Journal of Pediatrics》2023年第10期972-982,共11页世界儿科杂志（英文版）

基　　金：supported by the Key-Area Research and Development Program of Guangdong Province(2019B030335001);the Natural Science Foundation of Guangdong Province,China(2023A1515030192);the“Nutrition and Care of Maternal&Child Research Fund Project”of Biostime Institute of Nutrition&Care(2021BINCMCF053).

摘　　要：Background Previous studies have linked gestational diabetes(GDM)with allergies in offspring.However,the effect of specific glucose metabolism metrics was not well characterized,and the role of polyunsaturated fatty acids(PUFAs),a modifier of metabolism and the immune system,was understudied.We aimed to investigate the association between maternal GDM and allergic diseases in children and the interaction between glucose metabolism and PUFAs on allergic outcomes.Methods This prospective cohort study included 706 mother–child dyads from Guangzhou,China.Maternal GDM was diagnosed via a 75-g oral glucose tolerance test(OGTT),and dietary PUFAs were assessed using a validated food frequency questionnaire.Allergic disease diagnoses and the age of onset were obtained from medical records of children within three years old.Results Approximately 19.4%of women had GDM,and 51.3%of children had any allergic diseases.GDM was positively associated with any allergic diseases(hazard ratio[HR]1.40;95%confidence interval(CI)1.05–1.88)and eczema(HR 1.44;95%CI 1.02–1.97).A unit increase in OGTT after two hours(OGTT-2 h)glucose was associated with an 11%(95%CI 2%–21%)higher risk of any allergic diseases and a 17%(95%CI 1–36%)higher risk of food allergy.The positive associations between OGTT-2 h glucose and any allergic diseases were strengthened with decreased dietary a-linolenic acid(ALA)and increased n-6 PUFAs,linoleic acid(LA),LA/ALA ratio,and n-6/n-3 PUFA ratio.Conclusions Maternal GDM was adversely associated with early-life allergic diseases,especially eczema.We were the first to identify OGTT-2 h glucose to be more sensitive in inducing allergy risk and that dietary PUFAs might modify the associations.

关 键 词：Allergic disease Cohort study ECZEMA Gestational diabetes Polyunsaturated fatty acid 

分 类 号：R71[医药卫生—妇产科学]