血清β2-MG、Cys-C及肾功能相关指标在肾病综合征中的水平及临床意义分析  

The Levels and Clinical Significance of Serumβ2-MG,Cys-C and Renal Function Indexes in Nephrotic Syndrome

作　　者：柴志英 张航 杨梅 周洁 张如平 薛睿 刘蕊 CHAI Zhi-ying;ZHANG Hang;YANG Mei;ZHOU Jie;ZHANG Ru-ping;XUE Rui;LIU Rui(Department of Clinical Laboratory,The Second Affiliated Hospital of Guizhou University of Chinese Medicine,Guiyang,Guizhou,550001,China)

机构地区：[1]贵州中医药大学第二附属医院检验科,贵州贵阳550001

出　　处：《现代生物医学进展》2023年第16期3129-3132,3031,共5页Progress in Modern Biomedicine

基　　金：贵州省卫生计生委科学技术基金项目(gzujkj2017-1-064)。

摘　　要：目的:分析血清β2微球蛋白(β2-MG)、胱抑素C(Cys-C)及肾功能相关指标[24 h尿蛋白排泄率(UPE)、尿素(BUN)、肌酐(SCr)]在肾病综合征中的水平及临床意义。方法:选择我院自2019年3月至2022年3月收治的180例肾病综合征患者作为观察组,另选同期的180例健康体检者作为对照组。检测所有受试者血清β2-MG、Cys-C及肾功能相关指标;根据观察组患者治疗转归情况,分为转归组和未转归组,使用多因素Logistic回归分析血清β2-MG、Cys-C及肾功能相关指标与肾病综合征患者治疗未转归的关系,通过ROC下面积(AUC)评价血清β2-MG、Cys-C及肾功能相关指标对治疗未转归的预测效能。结果:观察组血清β2-MG、Cys-C、UPE、BUN、SCr水平均高于对照组(P<0.05);未转归组血清β2-MG、Cys-C、UPE、BUN、SCr水平均高于转归组(P<0.05);经多因素Logistic回归分析,血清β2-MG、Cys-C、UPE、BUN、SCr均是肾病综合征患者治疗未转归的独立预测因素(P<0.05);经ROC曲线分析,血清β2-MG、Cys-C、UPE、BUN联合SCr预测肾病综合征患者治疗未转归的AUC为0.910。结论:血清β2-MG、Cys-C及肾功能相关指标与肾病综合征密切相关,联合预测患者治疗未转归的效能较好,值得临床予以重视应用。Objective:To analyze the levels and clinical significance of serumβ2 microglobulin(β2-mg),cystatin C(Cys-C)and renal function related indexes[24 h urinary protein excretion rate(UPE),urea(BUN),creatinine(SCr)]in nephrotic syndrome.Methods:A total of 180 patients with nephrotic syndrome admitted to our hospital from March 2019 to March 2022 were selected as the observation group,and 180 healthy subjects during the same period were selected as the control group.Serumβ2-MG,Cys-C and renal function related indexes were detected.According to the treatment outcomes of patients in the observation group,they were divided into the outcome group and the non-outcome group.Multivariate Logistic regression was used to analyze the relationship between serumβ2-MG,Cys-C and related indexes of renal function and non-outcome after treatment in patients with nephrotic syndrome.The predictive efficacy of serum beta2-mg,Cys-C and renal function indexes in treatment non-outcome was evaluated by area under ROC.Results:The levels of serumβ2-MG,Cys-C,UPE,BUN and SCr in observation group were higher than those in control group(P<0.05).The levels of serumβ2-MG,Cys-C,UPE,BUN and SCr in non-outcome group were higher than those in outcome group(P<0.05).Multivariate Logistic regression analysis showed that serumβ2-MG,Cys-C,UPE,BUN and SCr were independent predictors of non-outcome in patients with nephrotic syndrome(P<0.05).According to ROC curve analysis,serumβ2-MG,Cys-C,UPE,BUN combined with SCr predicted that the AUC of patients with nephrotic syndrome without outcome after treatment was 0.910.Conclusion:Serumβ2-MG,Cys-C and renal function related indexes are closely related to nephrotic syndrome,and the combined prediction of treatment failure is good,worthy of clinical application.

关 键 词：肾病综合征 Β2微球蛋白 胱抑素C 肾功能 

分 类 号：R692[医药卫生—泌尿科学]