Factors of Fetal Origin in the Regulation of Labor Initiation and Preterm Birth  

作　　者：Longkun Ding Lu Gao 

机构地区：[1]Department of Physiology,Naval Medical University,Shanghai 200433,China [2]Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics,Shanghai 200135,China

出　　处：《Maternal-Fetal Medicine》2023年第4期238-243,共6页母胎医学杂志（英文）

基　　金：Research in the Gao's laboratory is supported by National Key Research and Development Project 2022YFC2704602 and 2022YFC2704502;National Natural Science Foundation of China 82120108011;Major Project of Shanghai Municipal Education Commission’s Scientific Research and Innovation Plan 2021-01-07-00-07-E00144;Strategic Collaborative Research Program of the Ferring Institute of Reproductive Medicine FIRMA200502.

摘　　要：Preterm birth is the leading cause of mortality and morbidity in newborns and children under 5 years-of-age.In order to improve the survival rate and quality of preterm infants,there is critical need to identify the specific mechanisms underlying the initiation of labor.Pregnancy represents a period of constant interactive dialog between mother and fetus.A disturbance in the pattern of maternal-fetal communication can induce physiological or pathological labor.Although a number of studies have investigated the contributions of maternal factors to the initiation of labor,the concept that fetal organ development and maternal adaptation are coordinated has emerged over recent years,thus emphasizing that factors of fetal origin may serve as hormonal signals for the initiation of labor.In this review,we summarize and discuss several specific mechanisms by which factors of fetal origin may influence parturition during term or preterm labor,including the specific regulation of fetal organs,including the lungs and accessory organs during pregnancy.Future research may focus on the specific pathways by which signals from the fetal lungs and other fetal organs interact with the maternal system to initiate eventual labor.

关 键 词：Premature birth Fetal origin factor PLACENTA Fetal membrane PARTURITION Term labor 

分 类 号：R714.21[医药卫生—妇产科学]