电活性骨修复材料研究进展  

Recent Development on Electroactive Biomaterials for Bone Tissue Engineering Application

作　　者：刘豪卿 吴程伟 翁文剑[1] 董灵庆 程逵[1] LIU Haoqing;WU Chengwei;WENG Wenjian;DONG Lingqing;CHENG Kui(School of Materials Science and Engineering,Zhejiang University,Hangzhou 310030,China;Stomatology Hospital,Zhejiang University School of Medicine,Hangzhou 310016,China)

机构地区：[1]浙江大学材料科学与工程学院,杭州310030 [2]浙江大学医学院附属口腔医院,杭州310016

出　　处：《硅酸盐学报》2023年第10期2544-2552,共9页Journal of The Chinese Ceramic Society

基　　金：国家自然基金面上项目(52271252)。

摘　　要：在骨修复领域中,通过构建天然骨再生微环境可加速骨修复进程。细胞微环境中的重要一环是生物电信号,它广泛存在于人体各种组织中,对干细胞分化、组织修复等具有关键调控作用。而电活性材料具有独特的电学特性,因此可借助电活性组织工程材料在骨缺损处模拟再生电学微环境,激发人体固有修复潜力,加速骨缺损的修复。本文根据所应用电学特性的区别,按铁电、压电、驻极效应和导电特性等类型,系统地综述了采用各种类型电活性材料促进骨修复的研究状况,为进一步研究提供了新思路。In the field of bone repair,the process of bone repair can be accelerated via building a natural bone regeneration microenvironment.An important part of the cellular microenvironment is the bioelectrical signal,which exists in various tissues of the body and plays a key role in regulating stem cell differentiation and tissue repair.The unique electrical properties of electroactive materials can be used to simulate a regenerative electrical microenvironment in bone defects,stimulating the body inherent repair potential and accelerating the repair of bone defects.According to the distinction of applied electrical signals,this review represented recent research work on the use of various types of electroactive materials to promote bone repair in terms of ferroelectric,piezoelectric,electret and conductive materials,providing some ideas to further enhance the therapeutic effect.

关 键 词：骨组织工程 电活性 铁电 压电 驻极体 电刺激 

分 类 号：R318.08[医药卫生—生物医学工程]