微纳米生物活性玻璃的制备与应用  

Preparation and Applications of Micro-Nano Bioactive Glass

作　　者：杨峥宇 赵夫健 杜昶[1,2,3] 陈晓峰 YANG Zhengyu;ZHAO Fujian;DU Chang;CHEN Xiaofeng(Department of Biomaterials,School of Materials Science and Engineering,South China University of Technology,Guangzhou 510641,China;National Engineering Research Center for Tissue Restoration and Reconstruction,Guangzhou 510006,China;Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education,South China University of Technology,Guangzhou 510006,China;Stomatological Hospital,Southern Medical University,Guangzhou 510280,China)

机构地区：[1]华南理工大学材料科学与工程学院生物材料系,广州510641 [2]国家人体组织功能重建工程技术研究中心,广州510641 [3]生物医用材料与工程教育部重点实验室,广州510641 [4]南方医科大学口腔医院,广州510641

出　　处：《硅酸盐学报》2023年第10期2553-2565,共13页Journal of The Chinese Ceramic Society

基　　金：国家自然科学基金(32000933,32171311,U1501245,51672088)。

摘　　要：微纳米生物活性玻璃(MNBG)已被证明具有良好的生物活性,在骨、齿及皮肤创面修复及组织工程领域受到高度关注。在近些年的研究中,多种金属离子在MNBG的制备过程中被掺入材料的网络结构中,从而赋予MNBG各种理化及生物学功能特性。然而,MNBG的离子释放产物与人体细胞之间相互作用的确切机制尚不完全清楚,这促使国内外研究者对离子掺杂的MNBG进行了较深入的研究。本文综述了有关MNBG的制备方法和工艺流程及其溶解产物在骨、齿等硬组织修复,皮肤组织修复,癌症治疗及细胞成像等方面的应用。为进一步开发应用于生物医学领域的新型MNBG提供参考。Micro-nano bioactive glass(MNBG)has a good biological activity and is widely used in tissue engineering.In recent years,a variety of metal ions are incorporated into the network structure of materials during the preparation of MNBG,thereby endowing MNBG with various physicochemical and biological functional properties.However,the exact mechanism of interaction between the ion release products of MNBG and human cells is not fully clarified.This review represented the preparation methods and processes of MNBG and the application of its lysates in bone and tooth and other hard tissue repair,skin tissue repair,cancer treatment and cell imaging.This review could provide a reference for the further development of MNBGs applied to the biomedical field.

关 键 词：微纳米生物活性玻璃 离子掺杂 生物活性 组织工程 

分 类 号：R318.08[医药卫生—生物医学工程]