双离子掺杂羟基磷灰石材料及其在硬组织工程中的应用  

Dual-Ions Substituted Hydroxyapatite Materials and Their Application in Hard Tissue Engineering

作　　者：钟振宇 徐军[1,2,3] 孙泽宇 范奕波 杜莹莹 张胜民[1,2,3] ZHONG Zhenyu;XU Jun;SUN Zeyu;FAN Yibo;DU Yingying;ZHANG Shengmin(Advanced Biomaterials and Tissue Engineering Center,Huazhong University of Science and Technology,Wuhan 430074,China;Institute of Regulatory Science for Medical Devices,Huazhong University of Science and Technology,Wuhan 430074,China;NMPA Research Base of Regulatory Science for Medical Devices,Wuhan 430074,China)

机构地区：[1]华中科技大学先进生物材料与组织工程研究中心,武汉430074 [2]华中科技大学医疗器械监管科学研究院,武汉430074 [3]国家药品监督管理局医疗器械监管科学研究基地,武汉430074

出　　处：《硅酸盐学报》2023年第10期2566-2578,共13页Journal of The Chinese Ceramic Society

基　　金：国家重点研发计划项目(2022YFC2405701);国家自然科学基金(82130061,32171331,31870960);中国科协青年人才托举工程(YESS20200077);湖北省自然科学基金(2021CFB609)。

摘　　要：羟基磷灰石(HA)是人体硬组织的主要无机组分,具有良好的生物活性及生物相容性,能够有效促进硬组织缺损的修复再生。研究表明:单一离子掺杂是一种有效提升HA材料生物活性的途径。而双离子掺杂不仅可实现对天然骨成分上的进一步仿生,还可以协同赋予HA材料更多功能特性,例如抗肿瘤、抗菌、促血管生成、免疫调节、医学成像等,拓展了HA材料在骨组织工程中的应用。对双离子掺杂HA材料的制备方法及原理进行了总结,并综述了双离子掺杂HA材料在硬组织工程中的潜在应用,最后对双离子掺杂HA材料的未来研究重点提出了建议和展望。Hydroxyapatite(HA)is the main inorganic constituent of human hard tissue.It can effectively accelerate the repair process of hard tissue defects due to its high bioactivity and biocompatibility.Ion doping is an effective approach to enhance the bioactivity of HA materials.On this basis,dual-ion substitution can make HA materials have a higher simulation to nature bone in composition and some functional features(i.e.,antitumor ability,antibacterial activity,pro-angiogenetic capacity,immunoregulatory and medical imaging capability).Dual-ion substitution greatly extends the applications of HA materials in bone tissue engineering.This review summarized the synthesis methods and their principles of dual-ion substituted HA(DIHA)materials,represented the applications of DIHA materials in hard tissue engineering,and finally proposed the future development direction of DIHA materials.

关 键 词：双离子掺杂 羟基磷灰石 硬组织工程 微量元素 

分 类 号：R318.08[医药卫生—生物医学工程]