元素掺杂调控磷酸钙形貌及其生物学功能效应  

Morphology and Biological Function of Calcium Phosphate Regulated by Elemental Doping

作　　者：常栋彪 白朕凡 黄浩[1,2] 杨安春 李思雨 翁杰 CHANG Dongbiao;BAI Zhenfan;HUANG Hao;YANG Anchun;LI Siyu;WENG Jie(College of Medicine,Institute of Biomedical Engineering,Southwest Jiaotong University,Chengdu 610031,China;Key Laboratory of Advanced Technologies of Materials Ministry of Education,School of Materials Science and Engineering,Southwest Jiaotong University,Chengdu 610031,China)

机构地区：[1]西南交通大学医学院(生物医学工程研究院),成都610031 [2]西南交通大学材料科学与工程学院,材料先进技术教育部重点实验室,成都610031

出　　处：《硅酸盐学报》2023年第10期2579-2593,共15页Journal of The Chinese Ceramic Society

基　　金：国家自然科学基金面上项目(52071277,22172120);四川省科技计划项目(2022YFSY0044)。

摘　　要：天然骨组织无机成分以磷酸钙为主,也含有多种维持生命活动所必需的其他元素,以保障骨组织正常生长发育。在磷酸钙生物材料制备中,元素掺杂能够有效调控磷酸钙形貌,并赋予其抗菌性、免疫调控、血管生成和骨诱导性等多种生物学功能。本文重点综述Mg、Zn、Sr、Cu、Ag、Co、Mn、稀土元素等金属元素和Se、Si、F等非金属元素单掺杂或共掺杂对多种磷酸钙形貌和生物学功能的调控效应,最后对磷酸钙生物材料的未来研究提出展望,以期为新型组织工程支架的研究提供参考。The inorganic composition of natural bone tissue is mainly calcium phosphate and consists of a variety of other elements necessary to maintain life activities to ensure the normal growth and development of bone tissue.In the preparation of calcium phosphate biomaterials,elemental doping can effectively regulate the morphology of calcium phosphate and have antibacterial properties,immune regulation,angiogenesis,osteoinduction and other biological functions.This review represented the regulatory effects of single-doping or co-doping of Mg,Zn,Sr,Cu,Ag,Co,Ag,Mn,and rare earth elements as well as Se,Si,and F in a variety of calcium phosphate on the structural morphology and biological function of materials.In addition,the future research work of calcium phosphate biomaterials was also proposed to provide a reference for the future research of novel scaffolds in tissue engineering.

关 键 词：磷酸钙 元素掺杂 形貌 生物学功能 

分 类 号：TQ174.75[化学工程—陶瓷工业] R318.08[化学工程—硅酸盐工业]