阻塞性睡眠呼吸暂停低通气综合征与骨代谢紊乱关系的研究进展  

Research progress on the relationship between obstructive sleep apnea hypopnea syndrome and bone metabolism disorder

作　　者：梅霞 周品益 吕云辉 单雪娇 王渝超 檀薇 Mei Xia;Zhou Pinyi;Lyu Yunhui;Shan Xuejiao;Wang Yuchao;Tan Wei(Department of Sleep Medicine,the Affiliated Hospital of Kunming University of Science and Technology,the First People′s Hospital of Yunnan Province,Kunming 650500,China)

机构地区：[1]昆明理工大学附属医院、云南省第一人民医院睡眠医学中心,昆明650500

出　　处：《国际呼吸杂志》2023年第10期1209-1214,共6页International Journal of Respiration

基　　金：国家自然科学基金(81760022);云南省科技厅科技计划项目(2018FE001(-107)、2018FE001(-295));云南省院士专家工作站(202105AF150022)。

摘　　要：阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是一种临床常见的睡眠呼吸障碍性疾病,可导致全身多系统、多器官损害。骨质疏松是一种以骨密度和骨质量下降、骨微结构破坏、骨脆性增加为特征的全身性骨病,可导致慢性疼痛和容易发生骨折。近年来的研究表明OSAHS与骨代谢紊乱存在相关性,OSAHS可通过引起氧化应激损伤、激活交感神经系统、介导炎症反应、促进炎症细胞因子表达等一系列途径影响骨代谢,但具体作用机制尚不明确。本文就当前OSAHS引起骨代谢紊乱可能机制的研究进展进行综述。Obstructive sleep apnea-hypopnea syndrome(OSAHS)is a common clinical sleep respiratory disorder,which can lead to systemic multi-system and multi-organ damage.Osteoporosis is a systemic bone disease characterized by the decrease of bone mineral density and bone mass,the destruction of bone microstructure,and the increase of bone fragility,which can lead to chronic pain and fracture.Recent studies have shown that OSAHS is associated with bone metabolic disorders.OSAHS can affect bone metabolism through oxidative stress,activating sympathetic nervous system,mediating inflammation,and promoting the expression of inflammatory cytokines,but the mechanism is not clear.This article reviews the recent research progress on the possible mechanism of OSAHS-induced bone metabolic disorder.

关 键 词：睡眠呼吸暂停综合征 骨质疏松 阻塞性 炎症介质 

分 类 号：R766[医药卫生—耳鼻咽喉科]