新疆维吾尔族人群甘油三酯-葡萄糖指数纵向轨迹与新发高血压的关系  

Relationship between longitudinal trajectory of triglyceride-glucose index and new-onset hypertension in Xinjiang Uygur population

作　　者：巴合古·依明尼亚孜 罗涛 张焕文 初蕾 阿丽亚·艾木都拉 迪丽胡玛尔·艾力 顾园申 戴江红[1] BAHEGU Yimingniyazi;LUO Tao;ZHANG Huanwen;CHU Lei;ALIYA Aimudula;DILIHUMAER Aili;GU Yuanshen;DAI Jianghong(School of Public Health,Xinjiang Medical University,Urumqi,Xinjiang 830017,China)

机构地区：[1]新疆医科大学公共卫生学院,新疆乌鲁木齐830017

出　　处：《中华高血压杂志》2023年第10期945-952,共8页Chinese Journal of Hypertension

基　　金：国家重点研发计划(2017YFC0907203);国家自然科学基金(82160640);省部共建中亚高发病成因与防治国家重点实验室(SKL-HIDCA-2020-ER)。

摘　　要：目的 探讨甘油三酯-葡萄糖指数(TyG)轨迹与新发高血压的关系,为高血压的防控提供科学依据。方法 以新疆多民族自然人群队列中的维吾尔族人群作为研究对象,依据其2017、2018、2019年度健康体检的TyG水平,采用SAS Proc Traj程序建立TyG轨迹模型并分组。随访各组人群2020年度高血压的发病情况,用多因素logistic回归模型分析不同TyG轨迹与新发高血压的关系。结果 纳入分析者7 420例,随访期间新发高血压435例,发病率为5.86%(标化发病率为7.51%)。通过轨迹分析模型最终确定3组不同的TyG轨迹组,分别为低水平-稳定组、中水平-稳定组、高水平-稳定组。高血压的发病率随着TyG轨迹水平的升高而增加,低水平-稳定组、中水平-稳定组、高水平-稳定组高血压的发病率分别为3.96%、6.34%、7.97%(P<0.05)。多因素logistic回归模型控制其他因素后,中水平-稳定组、高水平-稳定组高血压发病风险分别为低水平-稳定组的1.46倍(95%CI 1.13~1.90)与1.61倍(95%CI 1.11~2.33)。按照性别分层后,在女性中发现与低水平-稳定组相比,中水平-稳定组与高水平-稳定组高血压发病风险增加,但在男性中未见。敏感性分析发现,与低水平-稳定组相比,中水平-稳定组与高水平-稳定组高血压发病风险增加。结论 高TyG轨迹维吾尔族人群高血压发病风险增高。Objective To explore the relationship between triglyceride-glucose index(TyG) trajectory and new-onset hypertension and to provide a scientific basis for the prevention and control of hypertension. Methods The Uyghur population in the Xinjiang multiethnic cohort were used as the research object. According to the TyG level of physical examination in 2017, 2018, 2019, the TyG trajectory model was established by the SAS Proc Traj program and divided into groups. The incidence of hypertension was followed up in each group in 2020, and the association between different TyG trajectories and new-onset hypertension was analyzed using a multifactorial logistic regression model. Results A total of 7 420 patients were included, including 435 new-onset hypertension during follow-up, with an incidence of 5.86%(standard incidence of 7.51%). Through the trajectory analysis model, three different TyG trajectory groups were finally determined: low-level-stable group, middle-level-stable group, and high-level-stable group. The incidence of hypertension increased with the increase of TyG trajectory level. The incidence of hypertension in the low-level-stable group, the middle-level-stable group, and the high-level-stable group were 3.96%, 6.34%, and 7.97%,respectively(P<0.05). After the multifactorial logistic regression model controlling for other factors, the incidence of hypertension in the middle-level-stable group and the high-level-stable group of TyG was 1.46 times(95%CI 1.13-1.90) and 1.61 times(95%CI 1.11-2.33) higher than that in the low-level-stable group, respectively. According to gender stratification, in women, it was found that compared with the low-level-stable group, the risk of hypertension in the middle-level-stable group and the high-level-stable group increased, but it was not found in men. The sensitivity analysis also found that compared with the low-level-stable group, the risk of hypertension in the middle-level-stable group and the high-level-stable group increased. Conclusion Uyghur population with the l

关 键 词：新疆 维吾尔族 甘油三酯-葡萄糖指数 高血压 纵向轨迹 性别 

分 类 号：R544.1[医药卫生—心血管疾病]