中医药通过调控PI3K/Akt信号通路防治2型糖尿病肝脏胰岛素抵抗的研究进展  

Research progress of traditional Chinese medicine in the prevention and treatment of liver insulin resistance in type 2 diabetes mellitus by regulating PI3K/Akt signaling pathway

作　　者：朱海瑀 管洪艺 闫慧新 丁廷伟 宋柏林[1] ZHU Haiyu;GUAN Hongyi;YAN Huixin;DING Tingwei;SONG Bailin(Changchun University of Chinese Medicine,Changchun 130117,China)

机构地区：[1]长春中医药大学,长春130117

出　　处：《吉林中医药》2023年第11期1356-1360,共5页Jilin Journal of Chinese Medicine

基　　金：国家重点研发计划(2019YFC1709900)。

摘　　要：PI3K/Akt信号通路与肝脏胰岛素抵抗的发生发展密切相关,主要通过调控下游靶标蛋白如Fox O1、GSK-3β及GLUT2等,调节肝脏内糖脂代谢进而影响胰岛素抵抗程度和血糖水平。中药及中医外治法可以通过调控PI3K/Akt信号通路改善糖脂代谢水平、炎症反应及氧化应激反应,起到预防和治疗胰岛素抵抗及2型糖尿病的作用,且具有疗效明确、毒副作用少等优势,为临床中治疗本病提供更多的选择方案。The PI3K/Akt signaling pathway is closely related to the occurrence and development of liver insulin resistance,controlling the glucose and lipid metabolism in the liver by mainly regulating the downstream target proteins such as FoxO1,GSK-3βand GLUT2,thus affecting the degree of insulin resistance and blood glucose level.Traditional Chinese medicine and external treatments of traditional Chinese medicine can improve the glucose and lipid metabolism,inflammatory response and oxidative stress response by regulating the PI3K/Akt signaling pathway,and play a role in preventing and treating insulin resistance and type 2 diabetes,having the advantages of clear curative effect and less toxic and side effects,and providing more alternatives to the clinical treatment of this disease.

关 键 词：PI3K/AKT信号通路 肝脏 胰岛素抵抗 中医药 

分 类 号：R255.4[医药卫生—中医内科学]