FK506结合蛋白样蛋白在疾病中的作用的研究进展  

Advances in Research on FKBPL in Diseases

作　　者：侯静文 王晓宇[1] 詹添 王爱媛[1] HOU Jingwen;WANG Xiaoyu;ZHAN Tian;WANG Aiyuan(Shengjing Hospital Affiliated to China Medical University,Shenyang,110000,China)

机构地区：[1]中国医科大学附属盛京医院,沈阳市110000

出　　处：《医学分子生物学杂志》2023年第6期536-539,546,共5页Journal of Medical Molecular Biology

基　　金：辽宁省自然科学基金指导计划(No.2019-ZD-0738)。

摘　　要：FK506结合蛋白样蛋白(FK506-binding protein like,FKBPL)是亲免素家族的一员,其功能十分广泛,可以调控类固醇受体的信号转导,抑制肿瘤干细胞及肿瘤细胞的生长,并且能够作为肿瘤预后的生物学标志物。最新研究发现,它的N端区域存在抗血管生成结构域,可在体内和体外发挥抗血管生成作用。此外,FKBPL还与炎症、眼部疾病、心理疾病等诸多问题相关。文章主要从FKBPL的结构和功能出发,对FKBPL的功能研究进展进行综述,并探讨其在临床应用中的前景。FK506-binding protein like(FKBPL)is a member of the immunophilin family,and its functions are highly diverse.It can regulate the signal transduction of steroid receptors,inhibit the growth of tumor stem cells and tumor cells,and serve as a biological marker for tumor prognosis.Recent research has revealed the presence of an anti-angiogenesis domain in the N-terminal region of FKBPL,indicating its role in regulating angiogenesis both in vivo and in vitro.Additionally,FKBPL is associated with various issues such as inflammation,ocular diseases,and psychological disorders.This review aims to make a summary of the recent researches on FKBPL from the aspects of its structure and functions,and discusses its potential clinical applications.

关 键 词：FK506结合蛋白样蛋白 血管生成 肿瘤 内分泌 

分 类 号：R34[医药卫生—基础医学]